Primary mediastinal large B-cell lymphoma - PubMed (original) (raw)

Primary mediastinal large B-cell lymphoma

Anna Dabrowska-Iwanicka et al. Curr Hematol Malig Rep. 2014 Sep.

Abstract

Primary mediastinal B-cell lymphoma (PMBCL) is a relatively rare lymphoma subtype affecting mainly young adults. Its molecular signature and clinical features resemble classical Hodgkin lymphoma. The optimal chemotherapy for this lymphoma subtype has not been established. The addition of rituximab to anthracycline based chemotherapy improved response rates and survival. Many centers use R-CHOP as standard treatment, but the role of the intensified regimens and consolidation radiotherapy has to be clarified. Recent data coming from retrospective analyses and an ongoing prospective study addressing the problem of consolidation radiotherapy will help to better identify risk groups and apply risk-adapted and effective treatment strategies. The latest research has helped to understand molecular mechanisms of PMBCL pathogenesis and indicated targets of directed therapy for the future.

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Conflict of interest statement

Dr. Anna Dabrowska-Iwanicka declares no potential conflicts of interest relevant to this article.

Professor Jan A. Walewski reports grants and personal fees from Roche, grants from GSK, grants and personal fees from Celgene, grants and personal fees from Mundipharma, grants from Takeda, personal fees from Boehringer Ingelheim, and personal fees from Johnson and Johnson.

Figures

Fig. 1

Survival of PMBCL patients treated with different chemotherapy regimens – retrospective analysis of the Polish Lymphoma Research Group. Treatment outcomes of patients treated with different chemotherapy regimens: standard R-CHOP-21, dose-dense (R-CHOP-14), and dose-intense (GMALL B-ALL/NHL 2002 protocol and HDT/autoSCT) regimens

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