Transcriptomic correlates of organ failure extent in sepsis - PubMed (original) (raw)
doi: 10.1016/j.jinf.2014.12.010. Epub 2014 Dec 31.
María Heredia-Rodríguez 2, Esther Gomez-Sanchez 3, David Andaluz-Ojeda 4, Verónica Iglesias 5, Lucia Rico 6, Alicia Ortega 7, Estefanía Gomez-Pesquera 8, Pilar Liu 9, Marta Aragón 10, Jose Maria Eiros 11, Maria Ángeles Jiménez-Sousa 12, Salvador Resino 13, Ignacio Gómez-Herreras 14, Jesús F Bermejo-Martín 15, Eduardo Tamayo 16
Affiliations
- PMID: 25557485
- DOI: 10.1016/j.jinf.2014.12.010
Transcriptomic correlates of organ failure extent in sepsis
Raquel Almansa et al. J Infect. 2015 May.
Abstract
Objectives: Sepsis is characterised by the frequent presence of organ failure and marked immunologic alterations. We studied the association between the extent of organ failure and the transcriptomic response of septic patients.
Methods: Gene expression profiles in the blood of 74 surgical patients with sepsis were compared with those of 30 surgical patients with no sepsis. Differentially expressed genes were assessed for their correlation with the sequential organ failure (SOFA) score.
Results: The expression levels of a group of genes participating in the cell cycle (HIST1H1C, CKS2, CCNA2, CDK1, CCNB2, CIT, CCNB1, AURKA, RAD51), neutrophil protease activity (ELANE, ADORA3, MPO, MMP8, CTSG), IL-1R and IL-18R response correlated directly with SOFA and mortality. Genes involved in T cell (LCK, CD3G, CD3D, ZAP70, ICOS, CD3E, CD28, IL2RB, CD8B, CD8A, CD40LG, IL23A, CCL5, SH2D1A, ITK, CD247, TBX21, GATA3, CCR7, LEF1, STAT4) and NK cell immunity (CD244, KLRK1, KLRD1) were inversely associated with SOFA and mortality.
Conclusions: The extent of organ failure in sepsis correlates directly with the existence of imbalanced innate and adaptive responses at the transcriptomic level. Quantification of the expression levels of the genes identified here could contribute to the simultaneous assessment of disease severity and immunological alterations in sepsis.
Keywords: Immune response; Immunosupression; Microarrays; Organ failure extent; SOFA; Sepsis; Transcriptomics.
Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Similar articles
- Serum IL-6 and IL-1-ra with sequential organ failure assessment scores in septic patients receiving high-volume haemofiltration and continuous venovenous haemofiltration.
Ghani RA, Zainudin S, Ctkong N, Rahman AF, Wafa SR, Mohamad M, Manaf MR, Ismail R. Ghani RA, et al. Nephrology (Carlton). 2006 Oct;11(5):386-93. doi: 10.1111/j.1440-1797.2006.00600.x. Nephrology (Carlton). 2006. PMID: 17014550 Clinical Trial. - Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients.
Almansa R, Ortega A, Ávila-Alonso A, Heredia-Rodríguez M, Martín S, Benavides D, Martín-Fernandez M, Rico L, Aldecoa C, Rico J, López de Cenarruzabeitia I, Beltrán de Heredia J, Gomez-Sanchez E, Aragón M, Andrés C, Calvo D, Andaluz-Ojeda D, Liu P, Blanco-Antona F, Blanco L, Gómez-Herreras JI, Tamayo E, Bermejo-Martin JF. Almansa R, et al. Ann Surg. 2019 Mar;269(3):545-553. doi: 10.1097/SLA.0000000000002406. Ann Surg. 2019. PMID: 28692472 Clinical Trial. - Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients.
Kompoti M, Michopoulos A, Michalia M, Clouva-Molyvdas PM, Germenis AE, Speletas M. Kompoti M, et al. Immunobiology. 2015 Mar;220(3):414-21. doi: 10.1016/j.imbio.2014.10.006. Epub 2014 Oct 18. Immunobiology. 2015. PMID: 25454804 - Goodbye SIRS? Innate, trained and adaptive immunity and pathogenesis of organ dysfunction.
Ghnewa YG, Fish M, Jennings A, Carter MJ, Shankar-Hari M. Ghnewa YG, et al. Med Klin Intensivmed Notfmed. 2020 May;115(Suppl 1):10-14. doi: 10.1007/s00063-020-00683-2. Epub 2020 Apr 14. Med Klin Intensivmed Notfmed. 2020. PMID: 32291506 Review. English. - Organ dysfunction in patients with severe sepsis.
Vincent JL. Vincent JL. Surg Infect (Larchmt). 2006;7 Suppl 2:S69-72. doi: 10.1089/sur.2006.7.s2-69. Surg Infect (Larchmt). 2006. PMID: 16895511 Review.
Cited by
- Effect of acute exercise on gene expression in peripheral blood mononuclear cells of puberty children.
Du LJ, Song YH, Tang LX. Du LJ, et al. Sci Rep. 2024 Nov 14;14(1):27977. doi: 10.1038/s41598-024-77242-8. Sci Rep. 2024. PMID: 39543149 Free PMC article. - Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsis.
Guenther T, Coulibaly A, Velásquez SY, Schulte J, Fuderer T, Sturm T, Hahn B, Thiel M, Lindner HA. Guenther T, et al. J Inflamm (Lond). 2024 Oct 21;21(1):40. doi: 10.1186/s12950-024-00414-w. J Inflamm (Lond). 2024. PMID: 39434093 Free PMC article. - Gene expression profile analysis of severe influenza-based modulation of idiopathic pulmonary fibrosis.
Kong J, Chen L. Kong J, et al. Eur J Med Res. 2024 Oct 18;29(1):501. doi: 10.1186/s40001-024-02107-9. Eur J Med Res. 2024. PMID: 39420432 Free PMC article. - Identification of diagnostic candidate genes in COVID-19 patients with sepsis.
Li J, Pu S, Shu L, Guo M, He Z. Li J, et al. Immun Inflamm Dis. 2024 Oct;12(10):e70033. doi: 10.1002/iid3.70033. Immun Inflamm Dis. 2024. PMID: 39377750 Free PMC article. - Risk assessment with gene expression markers in sepsis development.
Garcia Lopez A, Schäuble S, Sae-Ong T, Seelbinder B, Bauer M, Giamarellos-Bourboulis EJ, Singer M, Lukaszewski R, Panagiotou G. Garcia Lopez A, et al. Cell Rep Med. 2024 Sep 17;5(9):101712. doi: 10.1016/j.xcrm.2024.101712. Epub 2024 Sep 3. Cell Rep Med. 2024. PMID: 39232497 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous