Loss of Harvey ras heterozygosity in oral squamous carcinoma - PubMed (original) (raw)
Loss of Harvey ras heterozygosity in oral squamous carcinoma
R E Howell et al. J Oral Pathol Med. 1989 Feb.
Abstract
This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c-Ha-ras-1 locus and that the tumour from one patient had lost that heterozygosity. The loss of c-Ha-ras-1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (11p) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of 11p deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.
Similar articles
- Proto-oncogene allelic variations in human squamous cell carcinomas of the larynx.
Dolcetti R, Pelucchi S, Maestro R, Rizzo S, Pastore A, Boiocchi M. Dolcetti R, et al. Eur Arch Otorhinolaryngol. 1991;248(5):279-85. doi: 10.1007/BF00176755. Eur Arch Otorhinolaryngol. 1991. PMID: 1679639 - Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.
Saranath D, Bhoite LT, Mehta AR, Sanghavi V, Deo MG. Saranath D, et al. J Cancer Res Clin Oncol. 1991;117(5):484-8. doi: 10.1007/BF01612771. J Cancer Res Clin Oncol. 1991. PMID: 1679760 - Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.
Weston A, Willey JC, Modali R, Sugimura H, McDowell EM, Resau J, Light B, Haugen A, Mann DL, Trump BF, et al. Weston A, et al. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5099-103. doi: 10.1073/pnas.86.13.5099. Proc Natl Acad Sci U S A. 1989. PMID: 2567993 Free PMC article. - Molecular lesions in human oral cancer: the Indian scene.
Saranath D, Bhoite LT, Deo MG. Saranath D, et al. Eur J Cancer B Oral Oncol. 1993 Apr;29B(2):107-12. doi: 10.1016/0964-1955(93)90031-9. Eur J Cancer B Oral Oncol. 1993. PMID: 7910088 Review. - Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck.
Field JK. Field JK. Eur J Cancer B Oral Oncol. 1992 Jul;28B(1):67-76. doi: 10.1016/0964-1955(92)90016-t. Eur J Cancer B Oral Oncol. 1992. PMID: 1330149 Review.
Cited by
- Proto-oncogene allelic variations in human squamous cell carcinomas of the larynx.
Dolcetti R, Pelucchi S, Maestro R, Rizzo S, Pastore A, Boiocchi M. Dolcetti R, et al. Eur Arch Otorhinolaryngol. 1991;248(5):279-85. doi: 10.1007/BF00176755. Eur Arch Otorhinolaryngol. 1991. PMID: 1679639 - The role of oncogenes and tumour-suppressor genes in the aetiology of oral, head and neck squamous cell carcinoma.
Field JK. Field JK. J R Soc Med. 1995 Jan;88(1):35P-39P. J R Soc Med. 1995. PMID: 7884768 Free PMC article. Review. No abstract available. - High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
Saranath D, Chang SE, Bhoite LT, Panchal RG, Kerr IB, Mehta AR, Johnson NW, Deo MG. Saranath D, et al. Br J Cancer. 1991 Apr;63(4):573-8. doi: 10.1038/bjc.1991.133. Br J Cancer. 1991. PMID: 2021541 Free PMC article. - Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Kiaris H, Spandidos DA, Jones AS, Vaughan ED, Field JK. Kiaris H, et al. Br J Cancer. 1995 Jul;72(1):123-8. doi: 10.1038/bjc.1995.287. Br J Cancer. 1995. PMID: 7599040 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials