An inducible endothelial cell surface glycoprotein mediates melanoma adhesion - PubMed (original) (raw)
. 1989 Dec 8;246(4935):1303-6.
doi: 10.1126/science.2588007.
Affiliations
- PMID: 2588007
- DOI: 10.1126/science.2588007
An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
G E Rice et al. Science. 1989.
Abstract
Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothelial cell surface glycoprotein, designated INCAM-110, appears to mediate adhesion of melanoma cells. In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line. Thus, activation of vascular endothelium in vivo that results in increased expression of INCAM-110 and ELAM-1 may promote tumor cell adhesion and affect the incidence and distribution of metastases.
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