Immune attack: the role of inflammation in Alzheimer disease - PubMed (original) (raw)
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doi: 10.1038/nrn3880.
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- PMID: 25991443
- DOI: 10.1038/nrn3880
Review
Immune attack: the role of inflammation in Alzheimer disease
Frank L Heppner et al. Nat Rev Neurosci. 2015 Jun.
Abstract
The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement.
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