Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes - PubMed (original) (raw)

doi: 10.1155/2015/841768. Epub 2015 Jul 5.

Yijun Wang 1, Junxia Wu 2, Suyi Liu 1, Ying Zhu 3, Shurong Lv 4, Ping Lin 4, Xiaoke Wang 1, Yan Xu 4, Shali Yu 1, Gang Chen 1, Quanyong Xiang 4

Affiliations

Current Smoking Dose-Dependently Associated with Decreased β-Cell Function in Chinese Men without Diabetes

Chun Wang et al. J Diabetes Res. 2015.

Abstract

The aim of this study was to evaluate the associations between chronic smoking and insulin resistance and β-cell function in Chinese men without diabetes. A total of 1,568 participants were recruited by multistage sampling. Using homeostatic model assessment (HOMA), geometric means of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) with 95% confidence interval (CI) were calculated by general linear model. Odds ratios (ORs) with 95% CI were estimated to evaluate the associations between smoking status and insulin resistance and β-cell deficiency under a logistic regression model. Current smokers had higher levels of 2 h glucose (6.66 versus 6.48 mmol/L) for oral glucose tolerance test and lower levels of fasting insulin (5.68 versus 6.03 mU/L) than never smokers. The adjusted means for HOMA-β (%) were 54.86 in current smokers and 58.81 in never smokers (P = 0.0257). Current smoking was associated with β-cell deficiency (OR 1.29, 95% CI 1.01-1.64) compared to never smoking. The β-cell function gradually decreased with increasing smoking intensity (P trend = 0.0026), and the differences were statistically significant when the pack-year of smoking was 20 or above. No association was observed between smoking status and HOMA-IR. Our study suggested that chronic smoking may dose-dependently suppress insulin secretion in Chinese men.

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Figures

Figure 1

Figure 1

The associations between smoking intensity and _β_-cell function. The triangles and squares represent crude odds ratios (ORs) and ORs after adjustment for age, education level, drinking status, body mass index, waist circumference, level of physical activity, hypertension, and dyslipidemia. The horizontal lines represent 95% confidence interval.

Figure 2

Figure 2

Dose-dependent effect of smoking intensity on _β_-cell deficiency. Fractional polynomial regression model is used to analyze the association between smoking intensity and _β_-cell deficiency. Solid line represents odds ratios; shaded area shows 95% confidence interval; dash line indicates the reference.

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