Association Between Growth of Geographic Atrophy and the Complement Factor I Locus - PubMed (original) (raw)
Association Between Growth of Geographic Atrophy and the Complement Factor I Locus
Zohar Yehoshua et al. Ophthalmic Surg Lasers Imaging Retina. 2015 Jul-Aug.
Abstract
The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P ≥ .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
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