Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor - PubMed (original) (raw)

Case Reports

. 2015 Nov;42(11):897-902.

doi: 10.1111/cup.12576. Epub 2015 Sep 16.

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Case Reports

Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor

Tadao Nakazawa et al. J Cutan Pathol. 2015 Nov.

Abstract

Porocarcinoma is a rare malignancy with glandular adnexal differentiation. A 38-year-old Japanese man noticed a subcutaneous mass in right inguinal region about 20 years prior to being examined. Radiological examinations demonstrated the mass, 11 × 10 cm in size, was in the subcutaneous fat tissue. Recently, the mass grew rapidly, and it was biopsied by an orthopedist based on clinical diagnosis of primary soft tissue tumor. Histopathological examination of the resected specimens also revealed that the tumor lacked involvement to the skin. Microscopically, the tumor was mainly composed of poroid cells with partially obvious squamous differentiation, accompanied by focal ductal structures immunoreactive for CEA and EMA. The tumor contained a low-grade area consisting of poroid cells and high-grade area with squamous differentiation. This histopathological heterogeneity suggested malignant transformation from poroma. The patient had the tumor in almost same size over the period of 20 years, which is the longest in the previous reports. This unique case of subcutaneous porocarcinoma is reported.

Keywords: adnexal neoplasm; histological heterogeneity; locating in the subcutaneous tissue.

© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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