NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease - PubMed (original) (raw)

Multicenter Study

. 2016 Feb;40(2):192-201.

doi: 10.1097/PAS.0000000000000523.

Alba Navarro, Alejandra Martinez-Trillos, Ricardo Molina-Urra, Blanca Gonzalez-Farre, Itziar Salaverria, Ferran Nadeu, Anna Enjuanes, Guillem Clot, Dolors Costa, Ana Carrio, Neus Villamor, Dolors Colomer, Antonio Martinez, Susanne Bens, Reiner Siebert, Andrew Wotherspoon, Sílvia Beà, Estella Matutes, Elias Campo

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Multicenter Study

NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease

Daniel Martinez et al. Am J Surg Pathol. 2016 Feb.

Abstract

Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known. We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease. IGHV genes were mutated in 9/13 (69%). Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as partners in each one of them. Copy number arrays showed aberrations in 69% of the tumors, including recurrent losses of 10q23, 14q31-q32, and 17p13 in 3, and 9p21 in 2 cases. Deletion of 7q31.3-q32.3 was present in only 1 case and no trisomies 3 or 18 were detected. NOTCH1 and MAP2K1 were mutated in 2 cases each, whereas BRAF, TP53, and SF3B1 were mutated each in single cases. No mutations were found in NOTCH2 or MYD88. Four of the 5 patients with aggressive disease had mutations in NOTCH1 (2 cases), TP53 (1 case), and MAP2K1 (1 case). The progression-free survival of patients with mutated genes was significantly shorter than in the unmutated (P=0.011). These findings show that SDRPL share some mutated genes but not chromosomal alterations, with other splenic lymphomas, that may confer a more aggressive behavior.

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