Characterization of quinolone resistance in Salmonella spp. isolates from food products and human samples in Brazil - PubMed (original) (raw)

Characterization of quinolone resistance in Salmonella spp. isolates from food products and human samples in Brazil

Bruno Rocha Pribul et al. Braz J Microbiol. 2016 Jan-Mar.

Abstract

Non-typhoidal salmonellosis is an important zoonotic disease caused by Salmonella enterica. The aim of this study was to investigate the prevalence of plasmid-mediated quinolone resistance in Salmonella spp. and its association with fluoroquinolone susceptibility in Brazil. A total of 129 NTS isolates (samples from human origin, food from animal origin, environmental, and animal) grouped as from animal (n=62) and human (n=67) food were evaluated between 2009 and 2013. These isolates were investigated through serotyping, antimicrobial susceptibility testing, and the presence of plasmid-mediated quinolone resistance (PMQR) genes (qnr, aac(6')-Ib) and associated integron genes (integrase, and conserved integron region). Resistance to quinolones and/or fluoroquinolones, from first to third generations, was observed. Fifteen isolates were positive for the presence of qnr genes (8 qnrS, 6 qnrB, and 1 qnrD) and twenty three of aac(6')-Ib. The conserved integron region was detected in 67 isolates as variable regions, from ±600 to >1000pb. The spread of NTS involving PMQR carriers is of serious concern and should be carefully monitored.

Keywords: Foodborne diseases; Quinolone resistance; Salmonella spp..

Copyright © 2015 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Majowicz S.E., Musto J., Scallan E. International collaboration on enteric disease ‘Burden of Illness’ studies. The global burden of nontyphoidal Salmonella gastroenteritis. Clin Infect Dis. 2010;50:882–889. - PubMed
    1. Greene S.K., Daly E.R., Talbot E.A. Recurrent multistate outbreak of Salmonella Newport associated with tomatoes from contaminated fields, 2005. Epidemiol Infect. 2008;136:157–165. - PMC - PubMed
    1. Yang B., Qu D., Zhang X. Prevalence and characterization of Salmonella serovars in retail meats of marketplace in Shaanxi, China. Int J Food Microbiol. 2010;141:63–72. - PubMed
    1. Tamang M.D., Nam H.M., Kim T.S., Jang G.C., Jung S.C., Lim S.K. Emergence of extended-spectrum beta-lactamase (CTX-M-15 and CTX-M-14)-producing nontyphoid Salmonella with reduced susceptibility to ciprofloxacin among food animals and humans in Korea. J Clin Microbiol. 2011;49:2671–2675. - PMC - PubMed
    1. Hur J., jawale C., Lee J.H. Antimicrobial resistance of Salmonella isolated from food animals: A review. Food Res Int. 2012;45:819–830.

MeSH terms

Substances

LinkOut - more resources