Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice - PubMed (original) (raw)
doi: 10.3920/BM2015.0083. Epub 2016 Mar 1.
Affiliations
- PMID: 26925603
- DOI: 10.3920/BM2015.0083
Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice
R Pothuraju et al. Benef Microbes. 2016 Jun.
Abstract
The effect of dietary supplementation of milk fermented with indigenous probiotic Lactobacillus plantarum (LP625) alone and in combination with herbs (Aloe vera and Gymnema sylvestre) was investigated on high fat diet (HFD, 60 kcal% fat) fed mice for 12 weeks. Administration of LP625 alone or in combination with both herbs lowered the final body weight, however, a significant difference was observed with LP625 supplemented Gymnema sylvestre only as compared to the HFD fed group (25.06±0.18 vs 27.29±0.72 g, P<0.05). Similarly, the epididymal fat mass, fasting blood glucose and serum insulin levels were significantly (P<0.05) decreased by all treatment groups. In addition, a protective effect against the rise in serum and liver triglycerides, and in liver total cholesterol levels was found with the consumption of LP625 alone or in combination with herbs. Furthermore, the HFD fed mice showed a remarkable increase in the epididymal fat cell size, whereas administration of LP625 alone or in combination with herbs exhibited a significant decrease in the size. Finally, a significant increase in the relative mRNA expression of thermogenic proteins, i.e. uncoupling protein-2 (UCP-2, 1.16±0.25 fold change, P<0.05) and a decrease in pro-inflammatory markers, such as tumour necrosis factor-α and interleukin-6 (1.55±0.18 and 3.10±0.58 fold change, respectively, P<0.05) were due to LP625 supplementation in the HFD fed group. This shows that LP625 alone or supplemented with herbs seems to protect against diet induced obesity by decreasing the body and epididymal fat weight through upregulation of UCP-2 expression and reduced expression of pro-inflammatory cytokines.
Keywords: Aloe vera; Gymnema sylvestre; Lactobacillus plantarum; high fat diet; obesity.
Similar articles
- Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6J mice.
Pothuraju R, Sharma RK, Chagalamarri J, Kavadi PK, Jangra S. Pothuraju R, et al. Food Funct. 2015 Nov;6(11):3576-84. doi: 10.1039/c5fo00781j. Epub 2015 Sep 1. Food Funct. 2015. PMID: 26327356 - Comparative evaluation of anti-obesity effect of Aloe vera and Gymnema sylvestre supplementation in high-fat diet fed C57BL/6J mice.
Pothuraju R, Sharma RK, Rather SA, Singh S. Pothuraju R, et al. J Intercult Ethnopharmacol. 2016 Jun 25;5(4):403-407. doi: 10.5455/jice.20160623122710. eCollection 2016 Sep-Dec. J Intercult Ethnopharmacol. 2016. PMID: 27757271 Free PMC article. - Antiobesity Effect of Garlic Extract Fermented by Lactobacillus plantarum BL2 in Diet-Induced Obese Mice.
Lee HS, Lim WC, Lee SJ, Lee SH, Lee JH, Cho HY. Lee HS, et al. J Med Food. 2016 Sep;19(9):823-9. doi: 10.1089/jmf.2016.3674. J Med Food. 2016. PMID: 27627701 - The effects of dietary supplements and natural products targeting glucose levels: an overview.
Hekmat-Ardakani A, Morshed-Behbahani B, Rahimi-Ardabili H, Ayati MH, Namazi N. Hekmat-Ardakani A, et al. Crit Rev Food Sci Nutr. 2023;63(23):6138-6167. doi: 10.1080/10408398.2022.2028716. Epub 2022 Jan 26. Crit Rev Food Sci Nutr. 2023. PMID: 35081820 Review. - Novel nutraceutic therapies for the treatment of metabolic syndrome.
Martínez-Abundis E, Méndez-Del Villar M, Pérez-Rubio KG, Zuñiga LY, Cortez-Navarrete M, Ramírez-Rodriguez A, González-Ortiz M. Martínez-Abundis E, et al. World J Diabetes. 2016 Apr 10;7(7):142-52. doi: 10.4239/wjd.v7.i7.142. World J Diabetes. 2016. PMID: 27076875 Free PMC article. Review.
Cited by
- Bifidobacterium longum 070103 Fermented Milk Improve Glucose and Lipid Metabolism Disorders by Regulating Gut Microbiota in Mice.
Jiang T, Li Y, Li L, Liang T, Du M, Yang L, Yang J, Yang R, Zhao H, Chen M, Ding Y, Zhang J, Wang J, Xie X, Wu Q. Jiang T, et al. Nutrients. 2022 Sep 29;14(19):4050. doi: 10.3390/nu14194050. Nutrients. 2022. PMID: 36235706 Free PMC article. - Isinglass Polysaccharides Regulate Intestinal-Barrier Function and Alleviate Obesity in High-Fat Diet Mice through the HO-1/Nrf2 Pathway and Intestinal Microbiome Environment.
Li G, Li S, Liu H, Zhang L, Gao J, Zhang S, Zou Y, Xia X, Ren X. Li G, et al. Nutrients. 2022 Sep 22;14(19):3928. doi: 10.3390/nu14193928. Nutrients. 2022. PMID: 36235584 Free PMC article. - Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.
Pothuraju R, Pai P, Chaudhary S, Siddiqui JA, Cox JL, Kaur S, Rachagani S, Roy HK, Bouvet M, Batra SK. Pothuraju R, et al. Aging (Albany NY). 2022 Mar 7;14(5):2025-2046. doi: 10.18632/aging.203935. Epub 2022 Mar 7. Aging (Albany NY). 2022. PMID: 35255004 Free PMC article. - Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food-Gut-Health Axis.
Ağagündüz D, Yılmaz B, Şahin TÖ, Güneşliol BE, Ayten Ş, Russo P, Spano G, Rocha JM, Bartkiene E, Özogul F. Ağagündüz D, et al. Foods. 2021 Dec 14;10(12):3099. doi: 10.3390/foods10123099. Foods. 2021. PMID: 34945650 Free PMC article. Review. - Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review.
Watanabe M, Risi R, Masi D, Caputi A, Balena A, Rossini G, Tuccinardi D, Mariani S, Basciani S, Manfrini S, Gnessi L, Lubrano C. Watanabe M, et al. Nutrients. 2020 Sep 20;12(9):2873. doi: 10.3390/nu12092873. Nutrients. 2020. PMID: 32962190 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical