Nerve growth factor (NGF)-treated nitrocellulose enhances and directs the regeneration of adult rat dorsal root axons through intraspinal neural tissue transplants - PubMed (original) (raw)

Nerve growth factor (NGF)-treated nitrocellulose enhances and directs the regeneration of adult rat dorsal root axons through intraspinal neural tissue transplants

J D Houle et al. Neurosci Lett. 1989.

Abstract

Severed adult rat dorsal roots were apposed to an intraspinal transplant of fetal spinal cord (FSC) tissue co-grafted with nerve growth factor (NGF)-treated nitrocellulose strips. Axonal regrowth from the injured roots was assessed by calcitonin gene-related peptide immunoreactivity (CGRP-IR). Dense fascicles of regenerating CGRP-IR axons lined the entire length of NGF-treated nitrocellulose, with many crossing the graft-host interface ventrally to extend into the host neuropil. In contrast, CGRP-IR axon regrowth was not promoted by untreated nitrocellulose implants. These results indicate that substrate bound NGF can promote and direct the intraspinal regeneration of a specific population of dorsal root axons.

PubMed Disclaimer

Similar articles

• Bridging a complete transection lesion of adult rat spinal cord with growth factor-treated nitrocellulose implants.
  Houle JD, Ziegler MK. Houle JD, et al. J Neural Transplant Plast. 1994 Apr-Jun;5(2):115-24. doi: 10.1155/NP.1994.115. J Neural Transplant Plast. 1994. PMID: 7703291 Free PMC article.
• Nerve growth factor in CNS repair.
  Varon S, Conner JM. Varon S, et al. J Neurotrauma. 1994 Oct;11(5):473-86. doi: 10.1089/neu.1994.11.473. J Neurotrauma. 1994. PMID: 7861441 Review.
• Target attraction: are developing axons guided by chemotropism?
  Tessier-Lavigne M, Placzek M. Tessier-Lavigne M, et al. Trends Neurosci. 1991 Jul;14(7):303-10. doi: 10.1016/0166-2236(91)90142-h. Trends Neurosci. 1991. PMID: 1719678 Review.

Cited by

• Cell transplantation to repair the injured spinal cord.
  Hall A, Fortino T, Spruance V, Niceforo A, Harrop JS, Phelps PE, Priest CA, Zholudeva LV, Lane MA. Hall A, et al. Int Rev Neurobiol. 2022;166:79-158. doi: 10.1016/bs.irn.2022.09.008. Epub 2022 Nov 9. Int Rev Neurobiol. 2022. PMID: 36424097 Free PMC article. No abstract available.
• Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity.
  Maier IC, Schwab ME. Maier IC, et al. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1611-34. doi: 10.1098/rstb.2006.1890. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16939978 Free PMC article. Review.
• The transitional zone and CNS regeneration.
  Fraher JP. Fraher JP. J Anat. 1999 Feb;194(Pt 2)(Pt 2):161-82. doi: 10.1046/j.1469-7580.1999.19420161.x. J Anat. 1999. PMID: 10337949 Free PMC article. Corrected and republished. Review.
• Blot and culture analysis of neuronotrophic factors in nerve regeneration chamber fluids.
  Bates DJ, Ranford JA, Mangelsdorf DC. Bates DJ, et al. Neurochem Res. 1991 Jun;16(6):621-8. doi: 10.1007/BF00965547. Neurochem Res. 1991. PMID: 1791911

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program