Physical Activity and Adiposity-related Inflammation: The MESA - PubMed (original) (raw)

Multicenter Study

Chantal A Vella et al. Med Sci Sports Exerc. 2017 May.

Abstract

Purpose: Physical activity is associated with decreased adiposity-related inflammation in adults. Whether this association is independent of central obesity is unknown but important for understanding the mechanisms associated with reducing cardiometabolic disease risk through physical activity. This study examined whether associations of physical activity and obesity-related inflammatory markers were independent of central adiposity.

Methods: Between 2002 and 2005, 1970 participants from the Multi-Ethnic Study of Atherosclerosis completed detailed health history and physical activity questionnaires, underwent physical measurements including computed tomography to quantify abdominal visceral and subcutaneous fat, and measurements of adiponectin, leptin, interleukin-6, tumor necrosis factor-alpha, and resistin. Statistical analyses included analysis of covariance and multivariable-adjusted regression.

Results: The mean (range) age of participants was 64.7 (55-84) yr and 50% were women. After adjustment for age and sex, and compared with the lowest quartile, inflammatory markers in the highest quartile of moderate-to-vigorous physical activity were 16% higher for adiponectin and 30%, 26%, and 9% lower for leptin, interleukin-6, and resistin, respectively (P < 0.05 for all). In linear regression adjusted for demographics, dyslipidemia, hypertension, diabetes, smoking, glomerular filtration rate, renin, and aldosterone, each standard deviation increment of moderate-to-vigorous physical activity was associated with significantly higher levels of adiponectin (β = 0.04) and lower levels of leptin (β = -0.06), interleukin-6 (β = -0.08), and resistin (β = -0.05, P < 0.05 for all). The associations with leptin, interleukin-6, and resistin were independent of total and central adiposity (P < 0.05), whereas the association between moderate-to-vigorous physical activity and adiponectin was attenuated by central adiposity (P > 0.05). There were no significant interactions by race/ethnicity or sex.

Conclusions: Moderate-to-vigorous physical activity was associated with a more favorable profile of inflammatory markers, independent of relevant cardiometabolic disease risk factors including central obesity.

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Figures

Figure 1

Figure 1

Multivariable-adjusted associations between quartiles of moderate-to-vigorous physical activity and levels of adipokines. Referent category: Quartile 1 – Quartile cutpoints (MET-minutes/week): Q1=<1830, Q2=1830-3561, Q3=3562-6370, Q4=>6370. Adjusted for age, sex, race/ethnicity, dyslipidemia, hypertension, diabetes, smoking, glomerular filtration rate, renin, aldosterone, height, and subcutaneous and visceral fat. B=slope; SEE, standard error of the estimate; Ln, natural logarithm, TNF-α, tumor necrosis factor alpha; IL-6, interleukin-6; *p<0.05

References

    1. Abramson JL, Vaccarino V. Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med. 2002;162:1286–92. - PubMed
    1. Ainsworth BE, Irwin ML, Addy CL, Whitt MC, Stolarczyk LM. Moderate physical activity patterns of minority women: the Cross-Cultural Activity Participation Study. J Women’s Health Gend Based Med. 1999;8(6):805–13. - PubMed
    1. Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exer. 2000;32(suppl9):S498–S504. - PubMed
    1. Arikawa AY, Thomas W, Schmitz KH, Kurzer MS. Sixteen weeks of exercise reduces c-reactive protein levels in young women. Med Sci Sports Exer. 2011;43(6):1002–9. - PubMed
    1. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clinica Chimica Acta. 2010;411:785–93. - PMC - PubMed

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