Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? - PubMed (original) (raw)

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Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?

Maximilian E Hölscher et al. Int J Mol Sci. 2016.

Abstract

In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus.

Keywords: diabetes mellitus; diabetic cardiomyopathy; heart.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

A compilation of arguments for and against the existence of diabetic cardiomyopathy in type 1 and type 2 diabetes. HF, heart failure; DC, diabetic cardiomyopathy; LV, left ventricular.

References

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