Neurons containing calcitonin gene-related peptide in the parabrachial nucleus project to the central nucleus of the amygdala - PubMed (original) (raw)
. 1988 Apr 15;270(3):416-26, 398-9.
doi: 10.1002/cne.902700310.
Affiliations
- PMID: 2836477
- DOI: 10.1002/cne.902700310
Neurons containing calcitonin gene-related peptide in the parabrachial nucleus project to the central nucleus of the amygdala
J S Schwaber et al. J Comp Neurol. 1988.
Abstract
The source, distribution, and morphology of axons displaying calcitonin gene-related peptide (CGRP) immunoreactivity in the central amygdaloid nucleus of the adult rat were investigated with immunohistochemical techniques, both alone and in combination with retrograde transport of fluorescent tracers. An extremely dense plexus of CGRP-immunoreactive axons is differentially concentrated within the lateral capsular and lateral central subdivisions of the central nucleus, and much lighter concentrations of labeled fibers are present in the rostral part of the medial subdivision. No immunoreactive neurons were observed in the central nucleus in any of the experimental animals. The immunoreactive axons characteristically form prominent pericellular terminal arborizations surrounding unlabeled neurons. The number of cells receiving this dense input increases at caudal levels of the central nucleus. Retrograde label of central nucleus neurons by dye transport from injections into the pontine parabrachial nucleus and the nucleus of the tractus solitarius combined with CGRP immunohistochemistry established that many neurons in the central nucleus which receive dense pericellular innervation from CGRP-immunoreactive axons are projecting caudally to the parabrachial nucleus or, to a lesser extent, to the nucleus tractus solitarii. Central amygdaloid injections of rhodamine-labeled microspheres or fluorogold followed by immunohistochemical localization of cellular CGRP immunoreactivity revealed that the central amygdaloid CGRP fiber plexus originates bilaterally from the parabrachial nucleus. These multipolar CGRP-containing neurons are preferentially concentrated in the external medial and external lateral subnuclei, in the ventral aspect of the parabrachial nucleus. These results relating central amygdaloid CGRP to ascending and descending brainstem pathways, taken together with the extreme density of the fiber plexus, strongly suggest the relevance of the CGRP input to central nucleus function in cardiovascular and other autonomic regulation.
Similar articles
- Corticotropin releasing factor neurons are innervated by calcitonin gene-related peptide terminals in the rat central amygdaloid nucleus.
Harrigan EA, Magnuson DJ, Thunstedt GM, Gray TS. Harrigan EA, et al. Brain Res Bull. 1994;33(5):529-34. doi: 10.1016/0361-9230(94)90079-5. Brain Res Bull. 1994. PMID: 8186998 - Parabrachial inputs to Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension: a light and electron microscopic study in the rat.
Takeuchi Y, Xie Q, Miki T, Matsumoto Y, Satriotomo I, Li HP, Gu H. Takeuchi Y, et al. Brain Res Bull. 2004 Aug 30;64(2):171-80. doi: 10.1016/j.brainresbull.2004.06.009. Brain Res Bull. 2004. PMID: 15342105 - Calcitonin gene-related peptide: detailed immunohistochemical distribution in the central nervous system.
Skofitsch G, Jacobowitz DM. Skofitsch G, et al. Peptides. 1985 Jul-Aug;6(4):721-45. doi: 10.1016/0196-9781(85)90178-0. Peptides. 1985. PMID: 3906594 - The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.
Palmiter RD. Palmiter RD. Trends Neurosci. 2018 May;41(5):280-293. doi: 10.1016/j.tins.2018.03.007. Trends Neurosci. 2018. PMID: 29703377 Free PMC article. Review.
Cited by
- Altered volume of the amygdala subregions in patients with chronic low back pain.
Gu SY, Shi FC, Wang S, Wang CY, Yao XX, Sun YF, Hu JB, Chen F, Pan PL, Li WH. Gu SY, et al. Front Neurol. 2024 Mar 28;15:1351335. doi: 10.3389/fneur.2024.1351335. eCollection 2024. Front Neurol. 2024. PMID: 38606278 Free PMC article. - Modulation of visceral pain by brain nuclei and brain circuits and the role of acupuncture: a narrative review.
Dou Z, Su N, Zhou Z, Mi A, Xu L, Zhou J, Sun S, Liu Y, Hao M, Li Z. Dou Z, et al. Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Front Neurosci. 2023. PMID: 38027491 Free PMC article. Review. - A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing.
Allen HN, Chaudhry S, Hong VM, Lewter LA, Sinha GP, Carrasquillo Y, Taylor BK, Kolber BJ. Allen HN, et al. Biol Psychiatry. 2023 Feb 15;93(4):370-381. doi: 10.1016/j.biopsych.2022.09.010. Epub 2022 Sep 16. Biol Psychiatry. 2023. PMID: 36473754 Free PMC article. - Sex Differences in CGRP Regulation and Function in the Amygdala in a Rat Model of Neuropathic Pain.
Presto P, Neugebauer V. Presto P, et al. Front Mol Neurosci. 2022 Jun 3;15:928587. doi: 10.3389/fnmol.2022.928587. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35726298 Free PMC article. - Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
Gandhi PJ, Gawande DY, Shelkar GP, Gakare SG, Kiritoshi T, Ji G, Misra B, Pavuluri R, Liu J, Neugebauer V, Dravid SM. Gandhi PJ, et al. Cells. 2021 Oct 3;10(10):2644. doi: 10.3390/cells10102644. Cells. 2021. PMID: 34685624 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials