β-arrestin-1: Bridging GPCRs to active TRP channels - PubMed (original) (raw)
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β-arrestin-1: Bridging GPCRs to active TRP channels
Zuying Chai et al. Channels (Austin). 2017.
No abstract available
Keywords: GPCR; TRP channel; TRPC3; arrestin; secretion.
Figures
Figure 1.
A schematic summary of GPCR-mediated TRP channel sensitization/activation. In addition to the sensitization or activation of TRP channels through the canonical G protein-dependent cascade signals (e.g., Gq-PLCβ-DAG-PKC and Gs-AC-cAMP-PKA signaling pathways), GPCRs also activate TRPC3 by recruiting PLCγ and β-arrestin-1, which assemble into a scaffold complex and directly open TRPC3 channels, thus triggering Ca2+-dependent acute catecholamine secretion from chromaffin cells. AC, adenylyl cyclase; β-arr1, β-arrestin-1; DAG, diacylglycerol.
Comment on
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