Novel Latency Reversal Agents for HIV-1 Cure - PubMed (original) (raw)
Review
Novel Latency Reversal Agents for HIV-1 Cure
Adam M Spivak et al. Annu Rev Med. 2018.
Abstract
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate HIV-1 in infected individuals. This review describes current pharmacologic approaches to reactivate the latent reservoir so that infected cells can be recognized and targeted, with the ultimate goal of achieving an HIV-1 cure.
Keywords: HIV-1 reservoir; NF-κB; SMAC; STAT5; benzotriazole; disulfiram; ingenol; latency reversal agents; protein kinase C; shock and kill; viral latency.
Figures
Figure. Signaling pathways leading to HIV-1 reactivation
Signaling steps involved in viral reactivation by SMAC mimetics, Disulfiram and Benzotriazole derivatives. For details, see main text. Adapted from references and .
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