Gene on short arm of human X chromosome complements murine tsA1S9 DNA synthesis mutation - PubMed (original) (raw)
Gene on short arm of human X chromosome complements murine tsA1S9 DNA synthesis mutation
C J Brown et al. Somat Cell Mol Genet. 1989 Mar.
Abstract
We have created somatic cell hybrids between the temperature-sensitive mouse cell line tsA1S9 and human cell lines in order to localize the human gene (A1S9T) complementing the cell cycle defect of the murine line. Segregation of the human X chromosome is completely concordant with growth at the nonpermissive temperature. Hybrids retaining the X chromosome are temperature-resistant, whereas those without a human X are temperature-sensitive. Further hybrids made using human cell lines with X-autosome translocations indicate that the A1S9T gene is located on the short arm of the human X chromosome.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials
Miscellaneous