NF-κB, inflammation, immunity and cancer: coming of age - PubMed (original) (raw)

Review

. 2018 May;18(5):309-324.

doi: 10.1038/nri.2017.142. Epub 2018 Jan 22.

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Review

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al. Nat Rev Immunol. 2018 May.

Abstract

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.

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