DNA modification of a maize transposable element correlates with loss of activity - PubMed (original) (raw)
DNA modification of a maize transposable element correlates with loss of activity
V L Chandler et al. Proc Natl Acad Sci U S A. 1986 Mar.
Abstract
An unstable allele of the bronze 2 (bz2) locus was isolated from a Robertson's Mutator Zea mays line containing a family of active transposable Mu elements. This mutation is somatically unstable, resulting in numerous revertant purple sectors on a bronze kernel. By following the variegated kernel phenotype through two generations, several lineages have been identified that have a distorted transmission of the mutant phenotype (fewer variegated kernels are produced than expected). Southern blot analysis of Mu elements in these plants demonstrates a correlation between an inhibition of digestion of Mu elements by certain restriction enzymes and the loss of somatic reversion at the mutant allele. The DNA modification can occur in all the Mu elements in a plant within one generation; however, plants have been identified that contain both modified and unmodified elements, suggesting that the modification can occur in a progressive manner. We hypothesize that the DNA modification results in nonfunctional elements.
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References
- J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
- Anal Biochem. 1973 Sep;55(1):328-30 - PubMed
- Proc Natl Acad Sci U S A. 1984 Jun;81(12):3825-9 - PubMed
- EMBO J. 1985 Apr;4(4):877-82 - PubMed
- Proc Natl Acad Sci U S A. 1984 Jul;81(13):4125-8 - PubMed
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