Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule - PubMed (original) (raw)

Comparative Study

Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule

H Matsushime et al. Mol Cell Biol. 1986 Aug.

Abstract

We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained a tyrosine kinase domain, a transmembrane domain, and a part of an extracellular domain carrying an N glycosylation site which was not acquired by UR2 sarcoma virus. The predicted structure of c-ros-1 is unique among the src family and clearly distinct from the human insulin receptor.

PubMed Disclaimer

Similar articles

• Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.
  Jong SM, Zong CS, Dorai T, Wang LH. Jong SM, et al. J Virol. 1992 Aug;66(8):4909-18. doi: 10.1128/JVI.66.8.4909-4918.1992. J Virol. 1992. PMID: 1321277 Free PMC article.
• Molecular cloning and characterization of avian sarcoma virus UR2 and comparison of its transforming sequence with those of other avian sarcoma viruses.
  Neckameyer WS, Wang LH. Neckameyer WS, et al. J Virol. 1984 Jun;50(3):914-21. doi: 10.1128/JVI.50.3.914-921.1984. J Virol. 1984. PMID: 6328022 Free PMC article.
• Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression.
  Neckameyer WS, Shibuya M, Hsu MT, Wang LH. Neckameyer WS, et al. Mol Cell Biol. 1986 May;6(5):1478-86. doi: 10.1128/mcb.6.5.1478-1486.1986. Mol Cell Biol. 1986. PMID: 3023892 Free PMC article.
• Structural and functional motifs of the Rous sarcoma virus src protein.
  Parsons JT, Wilkerson V, Parsons SJ. Parsons JT, et al. Gene Amplif Anal. 1986;4:1-19. Gene Amplif Anal. 1986. PMID: 2851527 Review.
• Avian sarcoma viruses.
  Wang LH, Hanafusa H. Wang LH, et al. Virus Res. 1988 Feb;9(2-3):159-203. doi: 10.1016/0168-1702(88)90030-5. Virus Res. 1988. PMID: 2833047 Review.

Cited by

• Activation of transforming potential of the human insulin receptor gene.
  Wang LH, Lin B, Jong SM, Dixon D, Ellis L, Roth RA, Rutter WJ. Wang LH, et al. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5725-9. doi: 10.1073/pnas.84.16.5725. Proc Natl Acad Sci U S A. 1987. PMID: 3039503 Free PMC article.
• Importance of ROS1 gene fusions in non-small cell lung cancer.
  Muminovic M, Carracedo Uribe CR, Alvarez-Pinzon A, Shan K, Raez LE. Muminovic M, et al. Cancer Drug Resist. 2023 Jun 9;6(2):332-344. doi: 10.20517/cdr.2022.105. eCollection 2023. Cancer Drug Resist. 2023. PMID: 37457125 Free PMC article. Review.
• ROS1-dependent cancers - biology, diagnostics and therapeutics.
  Drilon A, Jenkins C, Iyer S, Schoenfeld A, Keddy C, Davare MA. Drilon A, et al. Nat Rev Clin Oncol. 2021 Jan;18(1):35-55. doi: 10.1038/s41571-020-0408-9. Epub 2020 Aug 5. Nat Rev Clin Oncol. 2021. PMID: 32760015 Free PMC article. Review.
• His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.
  Leroy E, Defour JP, Sato T, Dass S, Gryshkova V, Shwe MM, Staerk J, Constantinescu SN, Smith SO. Leroy E, et al. J Biol Chem. 2016 Feb 5;291(6):2974-87. doi: 10.1074/jbc.M115.696534. Epub 2015 Dec 1. J Biol Chem. 2016. PMID: 26627830 Free PMC article.
• Isolation and characterization of the human Gs alpha gene.
  Kozasa T, Itoh H, Tsukamoto T, Kaziro Y. Kozasa T, et al. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2081-5. doi: 10.1073/pnas.85.7.2081. Proc Natl Acad Sci U S A. 1988. PMID: 3127824 Free PMC article.

References

1. 1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
2. 1. Mol Cell Biol. 1986 May;6(5):1478-86 - PubMed
3. 1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
4. 1. J Virol. 1981 Oct;40(1):268-75 - PubMed
5. 1. J Virol. 1982 Apr;42(1):143-52 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal