Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417 - PubMed (original) (raw)
Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417
R J Hawley et al. Neurology. 1987 Apr.
Abstract
Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-1417, IM twice a day for 1 month in an open-label trial, produced no objective improvement of strength in nine patients with ALS. No patient entered the double-blind, placebo-controlled phase of the trial.
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