The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease-A Review - PubMed (original) (raw)

Review

The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease-A Review

Bartosz Malinowski et al. Nutrients. 2020.

Abstract

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are a life-long, chronic, and relapsing problem affecting 11.2 million people worldwide. To date, there is pharmacological therapy to treat symptoms such as diarrhea, constipation, and abdominal cramping/pain. These medications also help to alleviate everyday discomfort; however, there are no curative therapies. Recent studies have investigated the combination of pharmacological treatment along with nutritional interventions to improve quality of life and risk of disease relapse. Dietary supplements, specifically probiotics, polyphenols, fibers, fatty acids and low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diets (FODMAP diets), have been closely looked at to determine their effect, if any, on the development of inflammatory bowel disease and its course of progression. Approximately 30 studies were carefully reviewed and analyzed to appreciate the value of these above-mentioned supplements and their influence on this gastrointestinal disease. After analysis, it has been demonstrated that by implementing fibers, polyphenols, and fatty acids, as well as keeping a low-saccharide diet for those patients with Crohn's disease and ulcerative colitis can improve quality of life and invoke clinical remission. Some polyphenols, specifically curcumin and resveratrol, have proved to decrease disease activity in studies reviewed. Although these studies have become a topic of recent interest, it would be of great value to doctors and patients alike, to continue in this direction of research and to improve the findings for best treatment substances and dosages. This would lead to increased quality of life and disease control leading to fewer complications in the future.

Keywords: Crohn’s disease; abdominal cramping/pain; constipation; diarrhea; fatty acids; fibers; inflammatory bowel disease; low FODMAP; polyphenols; probiotics; ulcerative colitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Cited by

TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model.
Bose D, Mondal A, Saha P, Kimono D, Sarkar S, Seth RK, Janulewicz P, Sullivan K, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Chatterjee S. Bose D, et al. Brain Sci. 2020 Aug 8;10(8):532. doi: 10.3390/brainsci10080532. Brain Sci. 2020. PMID: 32784362 Free PMC article.
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota.
Shabbir U, Rubab M, Daliri EB, Chelliah R, Javed A, Oh DH. Shabbir U, et al. Nutrients. 2021 Jan 12;13(1):206. doi: 10.3390/nu13010206. Nutrients. 2021. PMID: 33445760 Free PMC article. Review.
Advancements in Inflammatory Bowel Disease: A Narrative Review of Diagnostics, Management, Epidemiology, Prevalence, Patient Outcomes, Quality of Life, and Clinical Presentation.
Muzammil MA, Fariha F, Patel T, Sohail R, Kumar M, Khan E, Khanam B, Kumar S, Khatri M, Varrassi G, Vanga P. Muzammil MA, et al. Cureus. 2023 Jun 28;15(6):e41120. doi: 10.7759/cureus.41120. eCollection 2023 Jun. Cureus. 2023. PMID: 37519622 Free PMC article. Review.
Habitual Fish Oil Supplementation and Risk of Incident Inflammatory Bowel Diseases: A Prospective Population-Based Study.
Huang X, Li Y, Zhuang P, Liu X, Zhang Y, Zhang P, Jiao J. Huang X, et al. Front Nutr. 2022 Jul 12;9:905162. doi: 10.3389/fnut.2022.905162. eCollection 2022. Front Nutr. 2022. PMID: 35903442 Free PMC article.
Fermented Maillard Reaction Products by Lactobacillus gasseri 4M13 Alters the Intestinal Microbiota and Improves Dysfunction in Type 2 Diabetic Mice with Colitis.
Jeong YJ, Park HY, Nam HK, Lee KW. Jeong YJ, et al. Pharmaceuticals (Basel). 2021 Mar 28;14(4):299. doi: 10.3390/ph14040299. Pharmaceuticals (Basel). 2021. PMID: 33800583 Free PMC article.

References

1. Centers for Disease Control and Prevention. [(accessed on 16 November 2019)]; Available online: https://www.cdc.gov/features/inflammatory-bowel-disease/index.html.
1. World Gastroenterology Organization. [(accessed on 16 November 2019)]; Available online: https://www.worldgastroenterology.org/guidelines/global-guidelines/infla....
1. Bowel Disease Research Foundation. [(accessed on 16 November 2019)]; Available online: https://bdrf.org.uk/bowel-disease/ibd/
1. Yu Y.R., Rodriguez J.R. Clinical Presentation of Crohn’s, Ulcerative Colitis, and Indeterminate Colitis: Symptoms, Extraintestinal Manifestations, and Disease Phenotypes. Semin Pediatr Surg. 2017;2:349–355. doi: 10.1053/j.sempedssurg.2017.10.003. - DOI - PubMed
1. Flynn S., Eisenstein S. Inflamatorry Bowel Disease Presentation and Diagnosis. Surg. Clin. N. Am. 2019;99:1051–1062. doi: 10.1016/j.suc.2019.08.001. - DOI - PubMed

The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease-A Review - PubMed (original) (raw)