Primary structure of the met protein tyrosine kinase domain - PubMed (original) (raw)
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- PMID: 3325883
Comparative Study
Primary structure of the met protein tyrosine kinase domain
A M Chan et al. Oncogene. 1987 May.
Abstract
The primary structure of the protein tyrosine kinase domain of the human met gene has been determined from cDNA clones prepared from transcripts of the activated human met gene. These analyses reveal that the met kinase domain (located on human chromosome 7) possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. The results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein, which is encoded by human chromosome 1, exhibits homology to laminin B1.
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