Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil - PubMed (original) (raw)

. 2022 Jun;76(3):654-669.

doi: 10.1007/s11418-022-01614-5. Epub 2022 Mar 15.

Naoki Inoue 1, Takuya Konno 1, Yin Xu 1, Chinatsu Sakamoto 1, Mayuko Sone 1, Aya Shibasaka 1, Osamu Muraoka 1 2, Kiyofumi Ninomiya 1 2 3, Masayuki Yoshikawa 1, Yoshiaki Manse 1, Toshio Morikawa 4 5

Affiliations

• PMID: 35292883
• DOI: 10.1007/s11418-022-01614-5

Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil

Akifumi Nagatomo et al. J Nat Med. 2022 Jun.

Abstract

The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of 1-3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents, 2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyceride accumulation in HepG2 cells simultaneously treated with oleic acid and high glucose. In vivo assay of the methanol extract of I. paraguariensis revealed that 7 and 9 showed anti-hyperlipidemic activities in olive oil-treated mice. These results suggested that the saponin constituents of I. paraguariensis could be valuable bioactive marker for the anti-obesogenic activity.

Keywords: Anti-hyperlipidemic activity; Aquifoliaceae; Ilex paraguariensis; Mate; Mateoside; Matesaponin.

© 2022. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.

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