DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene - PubMed (original) (raw)
DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene
Y Tsujimoto et al. Proc Natl Acad Sci U S A. 1987 Mar.
Abstract
In most human follicular lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in the order 3' C gamma S gamma/mu JH 5'::5' bcl-2 3' (where C = constant, S = switch, and JH = joining segment of the heavy chain locus), suggesting that an inversion also occurred during the translocation process. The coding regions of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.
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References
- J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
- Cell. 1981 Dec;27(3 Pt 2):583-91 - PubMed
- Cancer Res. 1979 Aug;39(8):3119-28 - PubMed
- N Engl J Med. 1982 Nov 11;307(20):1231-6 - PubMed
- Proc Natl Acad Sci U S A. 1982 Sep;79(18):5611-5 - PubMed
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