Antibody and complement modulation of tumor cell growth in vitro and in vivo - PubMed (original) (raw)
Review
. 1978 Aug;37(10):2385-9.
- PMID: 354972
Review
Antibody and complement modulation of tumor cell growth in vitro and in vivo
W T Shearer et al. Fed Proc. 1978 Aug.
Abstract
Low doses of highly purified anti-TNP (trinitrophenyl) antibody specifically stimulated nucleoside uptake in TNP-substituted L cells and low doses of heterospecific anti-L cell antibody stimulated nucleoside incorporation, DNA synthesis, and cell growth in L cells in vitro. High concentrations of antibody inhibited these processes. Complement activated through C3 augmented the cytostimulatory effects of low concentrations of antibody and activated through C9 augmented the cytoinhibitory effects of antibody. One very early effect of cytostimulatory concentrations of antibody is activation of membrane carrier transport systems as seen with 45Ca2+ uptake. Growth of L cells in tissue culture in the continuous presence of a cytostimulatory concentration of antibody selected for a variant cell line that was less responsive to antibody, thought to be due to a blocking effect of increased amounts of sialic acid. In vivo experiments documented that the same antibody could modulate L cell tumor growth in T cell-depleted mice, depending on whether a low or high concentration of antibody was given passively. In the experimental systems used, therefore, antitumor antibody and complement directly modulate the growth of tumor cells.
Similar articles
- Humoral immunostimulation. IV. Role of complement.
Shearer WT, Atkinson JP, Frank MM, Parker CW. Shearer WT, et al. J Exp Med. 1975 Apr 1;141(4):736-52. J Exp Med. 1975. PMID: 1168690 Free PMC article. - Humoral immunostimulation. VI. Increased calcium uptake by cells treated with antibody and complement.
Shearer WT, Atkinson JP, Parker CW. Shearer WT, et al. J Immunol. 1976 Sep;117(3):973-80. J Immunol. 1976. PMID: 956662 - Correlation between covalent attachment of C3 and calcium uptake in antibody-stimulated L cells.
Shearer WT, Moore EG. Shearer WT, et al. Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):163-78. Res Commun Chem Pathol Pharmacol. 1984. PMID: 6484308 - Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo.
Drebin JA, Link VC, Greene MI. Drebin JA, et al. Oncogene. 1988 Apr;2(4):387-94. Oncogene. 1988. PMID: 2896329
Cited by
- Promotion of tumor invasion by cooperation of granulocytes and macrophages activated by anti-tumor antibodies.
Barbera-Guillem E, May KF Jr, Nyhus JK, Nelson MB. Barbera-Guillem E, et al. Neoplasia. 1999 Nov;1(5):453-60. doi: 10.1038/sj.neo.7900054. Neoplasia. 1999. PMID: 10933061 Free PMC article. - Immunologgical self-tolerance in allophenic and embryo-aggregated mice.
Prehn RT, Prehn LM. Prehn RT, et al. Theor Biol Med Model. 2010 Sep 20;7:38. doi: 10.1186/1742-4682-7-38. Theor Biol Med Model. 2010. PMID: 20854686 Free PMC article. - Antibody-induced changes in levels of cyclic adenosine monophosphate in leukaemic lymphocytes.
Virji M, Stevenson GT. Virji M, et al. Br J Cancer. 1979 Apr;39(4):434-40. doi: 10.1038/bjc.1979.77. Br J Cancer. 1979. PMID: 221000 Free PMC article. - Accelerated tumor growth mediated by sublytic levels of antibody-induced complement activation is associated with activation of the PI3K/AKT survival pathway.
Wu X, Ragupathi G, Panageas K, Hong F, Livingston PO. Wu X, et al. Clin Cancer Res. 2013 Sep 1;19(17):4728-39. doi: 10.1158/1078-0432.CCR-13-0088. Epub 2013 Jul 5. Clin Cancer Res. 2013. PMID: 23833306 Free PMC article. - Biphasic effect of a primary tumor on the growth of secondary tumor implants.
Bruzzo J, Chiarella P, Meiss RP, Ruggiero RA. Bruzzo J, et al. J Cancer Res Clin Oncol. 2010 Oct;136(10):1605-15. doi: 10.1007/s00432-010-0818-7. Epub 2010 Feb 21. J Cancer Res Clin Oncol. 2010. PMID: 20700688
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials
Miscellaneous