A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin - PubMed (original) (raw)
A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin
F Gejyo et al. Biochem Biophys Res Commun. 1985.
Abstract
Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microglobulin, with regard to its molecular weight of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-. These results demonstrate that the amyloid associated with chronic hemodialysis contains as major component a new form of amyloid fibril protein that is homologous to beta 2-microglobulin.
Similar articles
- Beta 2-microglobulin: a new form of amyloid protein associated with chronic hemodialysis.
Gejyo F, Odani S, Yamada T, Honma N, Saito H, Suzuki Y, Nakagawa Y, Kobayashi H, Maruyama Y, Hirasawa Y, et al. Gejyo F, et al. Kidney Int. 1986 Sep;30(3):385-90. doi: 10.1038/ki.1986.196. Kidney Int. 1986. PMID: 3537446 - Beta-2-microglobulin-associated amyloidosis in chronic hemodialysis patients with carpal tunnel syndrome.
Ullian ME, Hammond WS, Alfrey AC, Schultz A, Molitoris BA. Ullian ME, et al. Medicine (Baltimore). 1989 Mar;68(2):107-15. doi: 10.1097/00005792-198903000-00004. Medicine (Baltimore). 1989. PMID: 2646507 - Carpal tunnel syndrome and beta 2-microglobulin-related amyloidosis in chronic hemodialysis patients.
Gejyo F, Homma N, Arakawa M. Gejyo F, et al. Blood Purif. 1988;6(2):125-31. doi: 10.1159/000169494. Blood Purif. 1988. PMID: 3293616 No abstract available. - Dialysis-associated amyloidosis.
Sethi D. Sethi D. Ren Fail. 1993;15(3):349-51. doi: 10.3109/08860229309054943. Ren Fail. 1993. PMID: 8516489 Review.
Cited by
- Elevated concentration of beta2-microglobulin among patients with carpal tunnel syndrome in the course of primary Sjögren syndrome - a prospective observational study on 50 patients.
Kościńska-Shukla I, Jaskólska M, Chylińska M, Jaskólski D, Siemiński M, Chmielewski M. Kościńska-Shukla I, et al. Rheumatol Int. 2024 Sep;44(9):1739-1747. doi: 10.1007/s00296-024-05640-2. Epub 2024 Jul 6. Rheumatol Int. 2024. PMID: 38969943 Free PMC article. - Middle Molecular Uremic Toxin and Blood Purification Therapy.
Kawanishi H. Kawanishi H. J Clin Med. 2024 Jan 23;13(3):647. doi: 10.3390/jcm13030647. J Clin Med. 2024. PMID: 38337341 Free PMC article. Review. - β2-Microglobulin Elevates COL5A1 mRNA in the Subsynovial Connective Tissue of Patients Receiving Hemodialysis With Carpal Tunnel Syndrome.
Muneshige K, Onuma K, Sukegawa K, Otake Y, Inoue G, Takaso M, Uchida K. Muneshige K, et al. Cureus. 2022 Dec 12;14(12):e32423. doi: 10.7759/cureus.32423. eCollection 2022 Dec. Cureus. 2022. PMID: 36514703 Free PMC article. - Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis.
Nakajima K, Yamaguchi K, Noji M, Aguirre C, Ikenaka K, Mochizuki H, Zhou L, Ogi H, Ito T, Narita I, Gejyo F, Naiki H, Yamamoto S, Goto Y. Nakajima K, et al. Nat Commun. 2022 Oct 3;13(1):5689. doi: 10.1038/s41467-022-33247-3. Nat Commun. 2022. PMID: 36192385 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials