Molecular genetics of the achaete-scute gene complex of D. melanogaster - PubMed (original) (raw)
Molecular genetics of the achaete-scute gene complex of D. melanogaster
S Campuzano et al. Cell. 1985 Feb.
Abstract
The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by long stretches of DNA give rise to poly(A)+ RNAs of 1.6, 1.2, and 1.6 kb. Most DNA lesions associated with scute mutations map within the presumably untranscribed DNA. Their mutant phenotypes are stronger the closer the lesions are to the structural gene of one transcript (T4 RNA). Genetic and developmental data suggest that only this RNA is fundamental for the scute function. Its transcription might be perturbed by far removed DNA lesions. A second transcript is probably implicated in the lethal of scute embryonic function, while the third transcript is unnecessary for the differentiation of most macrochaetes. Two additional polyadenylated RNAs are transcribed from the achaete (1.1 kb) and yellow (1.9 kb) loci.
Similar articles
- Deletion analysis of the achaete-scute locus of Drosophila melanogaster.
Ruiz-Gómez M, Modolell J. Ruiz-Gómez M, et al. Genes Dev. 1987 Dec;1(10):1238-46. doi: 10.1101/gad.1.10.1238. Genes Dev. 1987. PMID: 3123318 - Excess function hairy-wing mutations caused by gypsy and copia insertions within structural genes of the achaete-scute locus of Drosophila.
Campuzano S, Balcells L, Villares R, Carramolino L, García-Alonso L, Modolell J. Campuzano S, et al. Cell. 1986 Jan 31;44(2):303-12. doi: 10.1016/0092-8674(86)90764-6. Cell. 1986. PMID: 3002632 - DNA map of mutations at the scute locus of Drosophila melanogaster.
Carramolino L, Ruiz-Gomez M, Guerrero Mdel C, Campuzano S, Modolell J. Carramolino L, et al. EMBO J. 1982;1(10):1185-91. doi: 10.1002/j.1460-2075.1982.tb00011.x. EMBO J. 1982. PMID: 16453435 Free PMC article. - The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development.
García-Bellido A, de Celis JF. García-Bellido A, et al. Genetics. 2009 Jul;182(3):631-9. doi: 10.1534/genetics.109.104083. Genetics. 2009. PMID: 19622761 Free PMC article. Review. - Morphogenesis of Drosophila melanogaster macrochaetes: cell fate determination for bristle organ.
Furman DP, Bukharina TA. Furman DP, et al. J Stem Cells. 2012;7(1):19-41. J Stem Cells. 2012. PMID: 23550342 Review.
Cited by
- Regulatory elements involved in the tissue-specific expression of the yellow gene of Drosophila.
Martin M, Meng YB, Chia W. Martin M, et al. Mol Gen Genet. 1989 Jul;218(1):118-26. doi: 10.1007/BF00330574. Mol Gen Genet. 1989. PMID: 2550760 - Dodeca satellite: a conserved G+C-rich satellite from the centromeric heterochromatin of Drosophila melanogaster.
Abad JP, Carmena M, Baars S, Saunders RD, Glover DM, Ludeña P, Sentis C, Tyler-Smith C, Villasante A. Abad JP, et al. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4663-7. doi: 10.1073/pnas.89.10.4663. Proc Natl Acad Sci U S A. 1992. PMID: 1584802 Free PMC article. - A highly polymorphic region in the X chromosome of Drosophila.
Haynes SR, Dawid IB. Haynes SR, et al. Mol Gen Genet. 1987 Aug;209(1):203-5. doi: 10.1007/BF00329861. Mol Gen Genet. 1987. PMID: 2823070 - 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.
Bellen HJ, Tong C, Tsuda H. Bellen HJ, et al. Nat Rev Neurosci. 2010 Jul;11(7):514-22. doi: 10.1038/nrn2839. Nat Rev Neurosci. 2010. PMID: 20383202 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous