Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line - PubMed (original) (raw)
- PMID: 3920529
- DOI: 10.1038/314330a0
Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line
S Rusconi et al. Nature. 1985.
Abstract
Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10-50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of mu and kappa transgenic products on the immunoglobulin heavy-chain rearrangement is possible.
Similar articles
- Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.
Ochi A, Hawley RG, Hawley T, Shulman MJ, Traunecker A, Köhler G, Hozumi N. Ochi A, et al. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6351-5. doi: 10.1073/pnas.80.20.6351. Proc Natl Acad Sci U S A. 1983. PMID: 6312453 Free PMC article. - Organization and expression of immunoglobulin genes in fetal liver hybridomas.
Perry RP, Kelley DE, Coleclough C, Kearney JF. Perry RP, et al. Proc Natl Acad Sci U S A. 1981 Jan;78(1):247-51. doi: 10.1073/pnas.78.1.247. Proc Natl Acad Sci U S A. 1981. PMID: 6787586 Free PMC article. - Mapping of the genes for mouse immunoglobulins M and D.
Mushinski JF. Mushinski JF. Crit Rev Immunol. 1983;4(2):169-95. Crit Rev Immunol. 1983. PMID: 6406143 Review. No abstract available. - Organization and expression of murine immunoglobulin genes.
Adams JM, Kemp DJ, Bernard O, Gough N, Webb E, Tyler B, Gerondakis S, Cory S. Adams JM, et al. Immunol Rev. 1981;59:5-32. doi: 10.1111/j.1600-065x.1981.tb00454.x. Immunol Rev. 1981. PMID: 6273295 Review. No abstract available.
Cited by
- Techniques to Study Antigen-Specific B Cell Responses.
Boonyaratanakornkit J, Taylor JJ. Boonyaratanakornkit J, et al. Front Immunol. 2019 Jul 24;10:1694. doi: 10.3389/fimmu.2019.01694. eCollection 2019. Front Immunol. 2019. PMID: 31396218 Free PMC article. Review. - B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.
Bhullar D, Nemazee D. Bhullar D, et al. Curr Top Microbiol Immunol. 2020;428:165-180. doi: 10.1007/82_2019_156. Curr Top Microbiol Immunol. 2020. PMID: 30919086 Free PMC article. Review. - One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.
Jacobsen JT, Mesin L, Markoulaki S, Schiepers A, Cavazzoni CB, Bousbaine D, Jaenisch R, Victora GD. Jacobsen JT, et al. J Exp Med. 2018 Oct 1;215(10):2686-2695. doi: 10.1084/jem.20172064. Epub 2018 Sep 4. J Exp Med. 2018. PMID: 30181412 Free PMC article. - B cell receptor editing in tolerance and autoimmunity.
Luning Prak ET, Monestier M, Eisenberg RA. Luning Prak ET, et al. Ann N Y Acad Sci. 2011 Jan;1217:96-121. doi: 10.1111/j.1749-6632.2010.05877.x. Epub 2011 Jan 5. Ann N Y Acad Sci. 2011. PMID: 21251012 Free PMC article. Review. - The evolution of human anti-double-stranded DNA autoantibodies.
Wellmann U, Letz M, Herrmann M, Angermüller S, Kalden JR, Winkler TH. Wellmann U, et al. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9258-63. doi: 10.1073/pnas.0500132102. Epub 2005 Jun 20. Proc Natl Acad Sci U S A. 2005. PMID: 15968001 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials