Analysis of the gene coding for the murine cellular tumour antigen p53 - PubMed (original) (raw)
Analysis of the gene coding for the murine cellular tumour antigen p53
B Bienz et al. EMBO J. 1984 Sep.
Abstract
A genomic clone containing the functional gene for the murine p53 cellular tumour antigen was isolated and structurally characterised. The gene contains at least 11 exons and 10 introns, the first intron possessing a length of 6.1 kb. Attempts to determine the exact 5' end of p53 mRNA were inconclusive, probably due to the presence of a remarkable stem and loop structure (delta G degrees approximately equal to -56 kcal/mol) in the 5' region of the gene. Suggestive similarities were found to exist between p53 and the protein product of the myc oncogene.
Similar articles
- Analysis of recombinant DNA clones specific for the murine p53 cellular tumor antigen.
Oren M, Bienz B, Givol D, Rechavi G, Zakut R. Oren M, et al. EMBO J. 1983;2(10):1633-9. doi: 10.1002/j.1460-2075.1983.tb01637.x. EMBO J. 1983. PMID: 6315396 Free PMC article. - [Isolation and characteristics of clones complementary to mRNA of the murine cellular tumor antigen p53].
Chumakov PM, Iotsova VS, Ninkina NN, Bukhman VL, Georgiev GP. Chumakov PM, et al. Genetika. 1988 Apr;24(4):602-12. Genetika. 1988. PMID: 2840339 Russian. - A variation in the structure of the protein-coding region of the human p53 gene.
Buchman VL, Chumakov PM, Ninkina NN, Samarina OP, Georgiev GP. Buchman VL, et al. Gene. 1988 Oct 30;70(2):245-52. doi: 10.1016/0378-1119(88)90196-5. Gene. 1988. PMID: 2905688 - Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences.
Wolf D, Rotter V. Wolf D, et al. Mol Cell Biol. 1984 Jul;4(7):1402-10. doi: 10.1128/mcb.4.7.1402-1410.1984. Mol Cell Biol. 1984. PMID: 6095069 Free PMC article. - The p53 cellular tumor antigen: gene structure, expression and protein properties.
Oren M. Oren M. Biochim Biophys Acta. 1985 Nov 12;823(1):67-78. doi: 10.1016/0304-419x(85)90015-0. Biochim Biophys Acta. 1985. PMID: 3902087 Review. No abstract available.
Cited by
- Translational Control in p53 Expression: The Role of 5'-Terminal Region of p53 mRNA.
Swiatkowska A, Dutkiewicz M, Zydowicz-Machtel P, Szpotkowska J, Janecki DM, Ciesiołka J. Swiatkowska A, et al. Int J Mol Sci. 2019 Oct 29;20(21):5382. doi: 10.3390/ijms20215382. Int J Mol Sci. 2019. PMID: 31671760 Free PMC article. Review. - Length and secondary structure of the 5' non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies.
Szpotkowska J, Swiatkowska A, Ciesiołka J. Szpotkowska J, et al. RNA Biol. 2019 Jan;16(1):25-41. doi: 10.1080/15476286.2018.1556084. Epub 2018 Dec 20. RNA Biol. 2019. PMID: 30518296 Free PMC article. - The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.
Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ. Hamard PJ, et al. Genes Dev. 2013 Sep 1;27(17):1868-85. doi: 10.1101/gad.224386.113. Genes Dev. 2013. PMID: 24013501 Free PMC article. - p53 selectively regulates developmental apoptosis of rod photoreceptors.
Vuong L, Brobst DE, Ivanovic I, Sherry DM, Al-Ubaidi MR. Vuong L, et al. PLoS One. 2013 Jun 20;8(6):e67381. doi: 10.1371/journal.pone.0067381. Print 2013. PLoS One. 2013. PMID: 23840687 Free PMC article. - Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.
Besaratinia A, Pfeifer GP. Besaratinia A, et al. FASEB J. 2010 Aug;24(8):2612-9. doi: 10.1096/fj.10-157263. Epub 2010 Apr 6. FASEB J. 2010. PMID: 20371617 Free PMC article. Review.
References
- Science. 1977 Apr 8;196(4286):180-2 - PubMed
- Cell. 1977 Nov;12(3):721-32 - PubMed
- Cell. 1978 Oct;15(2):687-701 - PubMed
- Cell. 1980 Jan;19(1):79-90 - PubMed
- Methods Enzymol. 1980;65(1):499-560 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous