Pluripotent teratocarcinoma-thymus somatic cell hybrids - PubMed (original) (raw)

Pluripotent teratocarcinoma-thymus somatic cell hybrids

R A Miller et al. Cell. 1976 Sep.

Abstract

We have produced a series of somatic cell hybrids by fusing pluripotent PCC4aza1 embryonal carcinoma ("teretocarcinoma") cells with thymocytes from young adult mice. When these hybrids form tumors in nu/nu or syngeneic mice, all the tumors contain a range of differentiated tissues, as well as embryonal carcinoma-like tissues. Some of the tumors produce alpha-fetoprotein. These results show that pluripotency in embryonal carcinoma cells need not to be abolished by the introduction of a complete diploid genome from a differentiated cell.

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