Evidence from in vitro studies that tolerance to self antigens is MHC-restricted - PubMed (original) (raw)
. 1984 Apr;308(5961):741-4.
doi: 10.1038/308741a0.
- PMID: 6232464
- DOI: 10.1038/308741a0
Evidence from in vitro studies that tolerance to self antigens is MHC-restricted
H G Rammensee et al. Nature. 1984 Apr.
Abstract
Mature T cells respond to foreign antigens in the context of self major histocompatibility complex (MHC)-encoded products: T helper cells recognize antigen in the context of class II molecules, while cytotoxic T cells (CTL) recognize antigen plus class I molecules. Recent evidence suggests that the MHC-restricted T cell is unable to recognize either the foreign antigen or the self-MHC product alone, but only a complex of the two. Unresponsiveness to self antigens--self tolerance--implies the deletion or suppression of clones of T cells having reactivity to self antigens. Here we demonstrate the presence in normal mice of T cells which recognize self antigens together with allogeneic MHC products. This finding suggests the MHC restriction of T-cell recognition during the entire process of T-cell ontogeny, that is, MHC restriction of self tolerance.
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