1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture - PubMed (original) (raw)
1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture
K Colston et al. Endocrinology. 1981 Mar.
Abstract
In this study we demonstrate the presence of specific, high-affinity receptors for 1,25-dihydroxyvitamin D3 in malignant melanoma. Receptors are present both in cultured melanoma cells and in melanoma tumor tissue produced by inoculation of cells into athymic rats. The receptor sediments at 3.25 on sucrose density gradients, possesses a preferential affinity for 1,25-(OH)2D3 and has an apparent Kd of 0.18 nM by Scatchard analysis. We also demonstrate that human melanoma cells are responsive to 1,25-(OH)2D3 in vitro. Inclusion of 1,25-(OH)2D3 in the culture medium produced a marked increase in cell doubling time. This inhibitory effect of the hormone on melanoma cell proliferation was dose-related and represents the first demonstration of a 1,25-(OH)2D3 mediated action on tumor cells.
Similar articles
- The ovary: a target organ for 1,25-dihydroxyvitamin D3.
Dokoh S, Donaldson CA, Marion SL, Pike JW, Haussler MR. Dokoh S, et al. Endocrinology. 1983 Jan;112(1):200-6. doi: 10.1210/endo-112-1-200. Endocrinology. 1983. PMID: 6291916 - Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes.
Matsumoto K, Hashimoto K, Kiyoki M, Yamamoto M, Yoshikawa K. Matsumoto K, et al. J Dermatol. 1990 Feb;17(2):97-103. doi: 10.1111/j.1346-8138.1990.tb03714.x. J Dermatol. 1990. PMID: 2158504 - 1 alpha, 25-Dihydroxyvitamin D3 specifically induces its own metabolism in a human cancer cell line.
Eisman JA, Sher E, Suva LJ, Frampton RJ, McLean FL. Eisman JA, et al. Endocrinology. 1984 Apr;114(4):1225-31. doi: 10.1210/endo-114-4-1225. Endocrinology. 1984. PMID: 6323135
Cited by
- Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer.
Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. Bikle DD, et al. Front Physiol. 2016 Jul 12;7:296. doi: 10.3389/fphys.2016.00296. eCollection 2016. Front Physiol. 2016. PMID: 27462278 Free PMC article. Review. - Effect of 1 alpha-hydroxycholecalciferol on psoriasis vulgaris: a pilot study.
Takamoto S, Onishi T, Morimoto S, Imanaka S, Yukawa S, Kozuka T, Kitano Y, Seino Y, Kumahara Y. Takamoto S, et al. Calcif Tissue Int. 1986 Dec;39(6):360-4. doi: 10.1007/BF02555172. Calcif Tissue Int. 1986. PMID: 3100000 - 25-Hydroxyvitamin D3 metabolism in a human leukemia cell line.
Bar-Shavit Z, Horst RL, Chappel JC, Ross FP, Gray RW, Teitelbaum SL. Bar-Shavit Z, et al. Calcif Tissue Int. 1986 Nov;39(5):328-33. doi: 10.1007/BF02555200. Calcif Tissue Int. 1986. PMID: 3102023 - A phase I study of the vitamin D3 analogue ILX23-7553 administered orally to patients with advanced solid tumors.
Jain RK, Trump DL, Egorin MJ, Fernandez M, Johnson CS, Ramanathan RK. Jain RK, et al. Invest New Drugs. 2011 Dec;29(6):1420-5. doi: 10.1007/s10637-010-9492-5. Epub 2010 Jul 27. Invest New Drugs. 2011. PMID: 20661623 Clinical Trial. - Calcium plus vitamin D supplementation and the risk of nonmelanoma and melanoma skin cancer: post hoc analyses of the women's health initiative randomized controlled trial.
Tang JY, Fu T, Leblanc E, Manson JE, Feldman D, Linos E, Vitolins MZ, Zeitouni NC, Larson J, Stefanick ML. Tang JY, et al. J Clin Oncol. 2011 Aug 1;29(22):3078-84. doi: 10.1200/JCO.2011.34.5967. Epub 2011 Jun 27. J Clin Oncol. 2011. PMID: 21709199 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical