Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts - PubMed (original) (raw)

Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts

D A Thorley-Lawson et al. Cell. 1982 Sep.

Abstract

We have developed a monoclonal antibody that detects the first human B-cell-specific differentiation antigen expressed on transformed B lymphoblasts. The antigen is termed B-LAST 1 and is found on B cells transformed in vitro with Epstein-Barr virus (EBV) and pokeweed mitogen; in vivo with EBV and antigen; and on neoplastic B cells from chronic lymphocytic leukemia and poorly differentiated lymphoma. The antigen has a molecular weight of 45,000 and was not found on cells of T, null or myeloid lineage, whether obtained from peripheral blood, lymph nodes, neoplasms or cell lines. The antigen is expressed at a much higher level on EBV-infected cells than on any other cell type studied, but does not appear to be virally encoded. The significance of this antigen in the process of viral and nonviral transformation and its possible role as a target for T-cell-mediated immunity against virus-infected cells is discussed.

PubMed Disclaimer

Similar articles

• BLAST-2 [EBVCS], an early cell surface marker of human B cell activation, is superinduced by Epstein Barr virus.
  Thorley-Lawson DA, Nadler LM, Bhan AK, Schooley RT. Thorley-Lawson DA, et al. J Immunol. 1985 May;134(5):3007-12. J Immunol. 1985. PMID: 2984280
• CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells.
  Long HM, Zuo J, Leese AM, Gudgeon NH, Jia H, Taylor GS, Rickinson AB. Long HM, et al. Blood. 2009 Jul 23;114(4):807-15. doi: 10.1182/blood-2008-12-194043. Epub 2009 May 14. Blood. 2009. PMID: 19443664
• Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody.
  Slovin SF, Frisman DM, Tsoukas CD, Royston I, Baird SM, Wormsley SB, Carson DA, Vaughan JH. Slovin SF, et al. Proc Natl Acad Sci U S A. 1982 Apr;79(8):2649-53. doi: 10.1073/pnas.79.8.2649. Proc Natl Acad Sci U S A. 1982. PMID: 6283539 Free PMC article.
• The biology of circulating B lymphocytes infected with Epstein-Barr virus during infectious mononucleosis.
  Robinson JE. Robinson JE. Yale J Biol Med. 1982 May-Aug;55(3-4):311-6. Yale J Biol Med. 1982. PMID: 6295008 Free PMC article. Review.
• Cell-mediated immunity against Epstein-Barr virus infected B lymphocytes.
  Klein E, Masucci MG. Klein E, et al. Springer Semin Immunopathol. 1982;5(1):63-73. doi: 10.1007/BF00201957. Springer Semin Immunopathol. 1982. PMID: 6314570 Review. No abstract available.

Cited by

• SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders.
  Kľoc D, Kurhajec S, Huniadi M, Sýkora J, Guman T, Šarišský M. Kľoc D, et al. Int J Mol Sci. 2024 Apr 4;25(7):4014. doi: 10.3390/ijms25074014. Int J Mol Sci. 2024. PMID: 38612827 Free PMC article. Review.
• Human natural killer cells: Form, function, and development.
  Mace EM. Mace EM. J Allergy Clin Immunol. 2023 Feb;151(2):371-385. doi: 10.1016/j.jaci.2022.09.022. Epub 2022 Oct 1. J Allergy Clin Immunol. 2023. PMID: 36195172 Free PMC article. Review.
• Comparative Expression Analysis of Inflammatory and Immune-related Genes in Cattle During Acute Infection with Foot-and-mouth Disease Virus in Egypt.
  El Nahas AF, Abd El Naby WSH, Khatab SA, Fergany AA, Rashed RR. El Nahas AF, et al. J Vet Res. 2021 Jan 26;65(1):39-44. doi: 10.2478/jvetres-2021-0005. eCollection 2021 Mar. J Vet Res. 2021. PMID: 33817393 Free PMC article.
• Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level.
  Gröger V, Wieland L, Naumann M, Meinecke AC, Meinhardt B, Rossner S, Ihling C, Emmer A, Staege MS, Cynis H. Gröger V, et al. Int J Mol Sci. 2020 Oct 23;21(21):7855. doi: 10.3390/ijms21217855. Int J Mol Sci. 2020. PMID: 33113941 Free PMC article.
• SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond.
  O'Connell P, Amalfitano A, Aldhamen YA. O'Connell P, et al. Vaccines (Basel). 2019 Nov 16;7(4):184. doi: 10.3390/vaccines7040184. Vaccines (Basel). 2019. PMID: 31744090 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program