Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes - PubMed (original) (raw)

. 1984 Jul;310(5973):143-5.

doi: 10.1038/310143a0.

• PMID: 6377090
• DOI: 10.1038/310143a0

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

J Milner. Nature. 1984 Jul.

Abstract

The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of p53 protein correlates with this commitment step. I show here that in unstimulated cells, a second form of p53 is synthesized and is restricted to G0.

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