Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma - PubMed (original) (raw)
- PMID: 6419124
- DOI: 10.1038/306806a0
Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma
T H Rabbitts et al. Nature. 1983.
Abstract
In Burkitt lymphoma the c-myc gene, the cellular homologue of the viral oncogene v-myc, has been implicated in the aetiology of this human B-cell malignancy. Burkitt lymphoma cells possess specific chromosomal rearrangements involving the region proximal to the c-myc gene and one of the three human immunoglobulin loci. The nature of the effect exerted by the immunoglobulin loci on the translocated c-myc gene is controversial: whereas some reports have suggested c-myc transcription is elevated in Burkitt lymphoma cells, others have suggested the level of transcription is unaffected by the translation. Recently, transcription enhancer elements have been identified in the intron between the JH and C mu segments of the heavy-chain immunoglobulin gene in mice. If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. We report here the identification of an enhancer element adjacent to the human C mu gene on normal chromosome 14, but this enhancer does not remain on the abnormal chromosome 14 to which the c-myc gene has been translocated in the Burkitt lymphoma cell line Raji. This element is, therefore, not available for control of the translocated c-myc gene in this case.
Similar articles
- Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma.
Gelmann EP, Psallidopoulos MC, Papas TS, Dalla-Favera R. Gelmann EP, et al. Nature. 1983 Dec 22-1984 Jan 4;306(5945):799-803. doi: 10.1038/306799a0. Nature. 1983. PMID: 6419123 - Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region.
Showe LC, Ballantine M, Nishikura K, Erikson J, Kaji H, Croce CM. Showe LC, et al. Mol Cell Biol. 1985 Mar;5(3):501-9. doi: 10.1128/mcb.5.3.501-509.1985. Mol Cell Biol. 1985. PMID: 3921823 Free PMC article. - Translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells.
Croce CM, Erikson J, ar-Rushdi A, Aden D, Nishikura K. Croce CM, et al. Proc Natl Acad Sci U S A. 1984 May;81(10):3170-4. doi: 10.1073/pnas.81.10.3170. Proc Natl Acad Sci U S A. 1984. PMID: 6328505 Free PMC article. - Translocations among antibody genes in human cancer.
Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R. Leder P, et al. Science. 1983 Nov 18;222(4625):765-71. doi: 10.1126/science.6356357. Science. 1983. PMID: 6356357 Review. - New genetics of Burkitt's lymphoma and other non-Hodgkin's lymphomas.
Aisenberg AC. Aisenberg AC. Am J Med. 1984 Dec;77(6):1083-90. doi: 10.1016/0002-9343(84)90192-x. Am J Med. 1984. PMID: 6439038 Review.
Cited by
- Discovery platform for inhibitors of IgH gene enhancer activity.
Dolloff NG. Dolloff NG. Cancer Biol Ther. 2019;20(4):571-581. doi: 10.1080/15384047.2018.1538615. Epub 2018 Nov 27. Cancer Biol Ther. 2019. PMID: 30481117 Free PMC article. - AID to overcome the limitations of genomic information by introducing somatic DNA alterations.
Honjo T, Muramatsu M, Nagaoka H, Kinoshita K, Shinkura R. Honjo T, et al. Proc Jpn Acad Ser B Phys Biol Sci. 2006 May;82(3):104-20. doi: 10.2183/pjab.82.104. Proc Jpn Acad Ser B Phys Biol Sci. 2006. PMID: 25873751 Free PMC article. Review. - Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.
Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. Machida K, et al. J Immunol. 2010 Dec 1;185(11):6985-98. doi: 10.4049/jimmunol.1000618. Epub 2010 Oct 25. J Immunol. 2010. PMID: 20974981 Free PMC article. - Transcriptional consequences of topoisomerase inhibition.
Collins I, Weber A, Levens D. Collins I, et al. Mol Cell Biol. 2001 Dec;21(24):8437-51. doi: 10.1128/MCB.21.24.8437-8451.2001. Mol Cell Biol. 2001. PMID: 11713279 Free PMC article. - Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line.
Faris M, Kokot N, Stahl N, Nel AE. Faris M, et al. Immunology. 1997 Mar;90(3):350-7. doi: 10.1111/j.1365-2567.1997.00350.x. Immunology. 1997. PMID: 9155640 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials