Human and rodent DNA sequence comparisons: a mosaic model of genomic evolution - PubMed (original) (raw)
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Human and rodent DNA sequence comparisons: a mosaic model of genomic evolution
B F Koop. Trends Genet. 1995 Sep.
Abstract
Three patterns of DNA sequence conservation have been identified from five human and rodent genomic sequence comparisons. First, a divergent pattern was observed in the noncoding sequences of the beta-globin and gamma-crystallin gene clusters, and second, a highly conserved pattern was observed in the noncoding regions of the T cell receptor C alpha-C delta, and the alpha- and beta-myosin-heavy-chain genes. A third, mixed pattern has also been found in the immunoglobulin IgH C mu-C delta gene region. These three patterns of genomic evolution pose the fascinating possibility that large portions of the genome evolve at different rates.
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