Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA - PubMed (original) (raw)
. 1993 Dec;143(6):1579-85.
Affiliations
- PMID: 7504884
- PMCID: PMC1887279
Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA
G J Adema et al. Am J Pathol. 1993 Dec.
Abstract
The glycoproteins recognized by monoclonal antibody (MAb) NKI-beteb are among the best diagnostic markers for human melanoma. MAb NKI-beteb reacts with melanoma cells throughout tumor development and does not cross-react with other tumor or normal cells, except for cells of the melanocytic lineage. Two other melanocyte lineage-specific MAbs, HMB-50 and HMB-45, show a specificity and staining pattern strikingly similar to the ones observed for NKI-beteb. Herein, we demonstrate that all three MAbs recognize protein products encoded by a single cDNA. Expression of this cDNA in BLM cells results in immunoreactivity with all three MAbs. In addition, we demonstrate co-distribution of the RNA species detected by the cDNA with the proteins recognized by the MAbs in tissue sections.
Similar articles
- A monoclonal antibody specific for cells of the melanocyte lineage.
Vennegoor C, Hageman P, Van Nouhuijs H, Ruiter DJ, Calafat J, Ringens PJ, Rümke P. Vennegoor C, et al. Am J Pathol. 1988 Jan;130(1):179-92. Am J Pathol. 1988. PMID: 3276209 Free PMC article. - Immunohistochemistry and in situ hybridization in the study of human skin melanocytes.
Passeron T, Coelho SG, Miyamura Y, Takahashi K, Hearing VJ. Passeron T, et al. Exp Dermatol. 2007 Mar;16(3):162-70. doi: 10.1111/j.1600-0625.2006.00538.x. Exp Dermatol. 2007. PMID: 17286807 Review. - S-100 protein remains a practical marker for melanocytic and other tumours.
Cochran AJ, Lu HF, Li PX, Saxton R, Wen DR. Cochran AJ, et al. Melanoma Res. 1993 Oct;3(5):325-30. doi: 10.1097/00008390-199310000-00004. Melanoma Res. 1993. PMID: 8292888 Review.
Cited by
- Human Papillary and Reticular Fibroblasts Show Distinct Functions on Tumor Behavior in 3D-Organotypic Cultures Mimicking Melanoma and HNSCC.
Wu S, Rietveld M, Hogervorst M, de Gruijl F, van der Burg S, Vermeer M, van Doorn R, Welters M, El Ghalbzouri A. Wu S, et al. Int J Mol Sci. 2022 Oct 1;23(19):11651. doi: 10.3390/ijms231911651. Int J Mol Sci. 2022. PMID: 36232952 Free PMC article. - Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL.
Mitchell SM, Graham M, Liu X, Leonhardt RM. Mitchell SM, et al. Sci Rep. 2021 Apr 8;11(1):7730. doi: 10.1038/s41598-021-87259-y. Sci Rep. 2021. PMID: 33833328 Free PMC article. - ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells.
Bossi G, Buisson S, Oates J, Jakobsen BK, Hassan NJ. Bossi G, et al. Cancer Immunol Immunother. 2014 May;63(5):437-48. doi: 10.1007/s00262-014-1525-z. Epub 2014 Feb 15. Cancer Immunol Immunother. 2014. PMID: 24531387 Free PMC article. - Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene.
Steagall WK, Pacheco-Rodriguez G, Glasgow CG, Ikeda Y, Lin JP, Zheng G, Moss J. Steagall WK, et al. Am J Pathol. 2013 Sep;183(3):938-50. doi: 10.1016/j.ajpath.2013.05.024. Epub 2013 Jul 16. Am J Pathol. 2013. PMID: 23867796 Free PMC article. - Cultivation-dependent plasticity of melanoma phenotype.
Kodet O, Dvořánková B, Krejčí E, Szabo P, Dvořák P, Štork J, Krajsová I, Dundr P, Smetana K Jr, Lacina L. Kodet O, et al. Tumour Biol. 2013 Dec;34(6):3345-55. doi: 10.1007/s13277-013-0905-x. Epub 2013 Jun 12. Tumour Biol. 2013. PMID: 23757003
References
- Virology. 1973 Apr;52(2):456-67 - PubMed
- J Histochem Cytochem. 1992 Nov;40(11):1761-7 - PubMed
- Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
- Proc Natl Acad Sci U S A. 1982 Mar;79(6):2018-22 - PubMed
- J Cancer Res Clin Oncol. 1984;108(2):197-203 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials