CD40 ligation in B cell activation, isotype switching and memory development - PubMed (original) (raw)
Review
CD40 ligation in B cell activation, isotype switching and memory development
D Gray et al. Semin Immunol. 1994 Oct.
Abstract
Interaction of CD40 on B cells with its ligand on activated T helper cells is crucial for the generation of mature T-dependent antibody responses. Experimental observations suggest that CD40 ligation acts at several points in B cell differentiation; however, it is not clear whether the consequences of ligation are direct or indirect. While its role in B cell activation is clearly direct we discuss the several ways in which it might drive isotype switching, the influence that it has on the development of memory B cells and the possibility that certain types of T-dependent antibody response are CD40L-independent. Experiments in which the ligation of CD40 is blocked in vivo reveal that early CD40 signals are important for the development of memory B cells but this may only reflect the ability of 'memory precursors' generated by CD40 ligation to accept subsequent programming or survival signals.
Similar articles
- CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B cells.
Aversa G, Punnonen J, Carballido JM, Cocks BG, de Vries JE. Aversa G, et al. Semin Immunol. 1994 Oct;6(5):295-301. doi: 10.1006/smim.1994.1038. Semin Immunol. 1994. PMID: 7532459 Review. - Bidirectional regulation of human B cell responses by CD40-CD40 ligand interactions.
Miyashita T, McIlraith MJ, Grammer AC, Miura Y, Attrep JF, Shimaoka Y, Lipsky PE. Miyashita T, et al. J Immunol. 1997 May 15;158(10):4620-33. J Immunol. 1997. PMID: 9144474 - B cells from CBA/N mice do not proliferate following ligation of CD40.
Hasbold J, Klaus GG. Hasbold J, et al. Eur J Immunol. 1994 Jan;24(1):152-7. doi: 10.1002/eji.1830240123. Eur J Immunol. 1994. PMID: 7517360 - Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns.
Durandy A, De Saint Basile G, Lisowska-Grospierre B, Gauchat JF, Forveille M, Kroczek RA, Bonnefoy JY, Fischer A. Durandy A, et al. J Immunol. 1995 Feb 15;154(4):1560-8. J Immunol. 1995. PMID: 7530739 - The expansive role of CD40 and its ligand, gp39, in immunity.
Foy TM, Durie FH, Noelle RJ. Foy TM, et al. Semin Immunol. 1994 Oct;6(5):259-66. doi: 10.1006/smim.1994.1034. Semin Immunol. 1994. PMID: 7532456 Review.
Cited by
- CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells.
Choi H, Lee HJ, Sohn HJ, Kim TG. Choi H, et al. BMC Immunol. 2023 Jun 30;24(1):15. doi: 10.1186/s12865-023-00547-2. BMC Immunol. 2023. PMID: 37391734 Free PMC article. - Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters.
Piano Mortari E, Pulvirenti F, Marcellini V, Terreri S, Salinas AF, Ferrari S, Di Napoli G, Guadagnolo D, Sculco E, Albano C, Guercio M, Di Cecca S, Milito C, Garzi G, Pesce AM, Bonanni L, Sinibaldi M, Bordoni V, Di Cecilia S, Accordini S, Castilletti C, Agrati C, Quintarelli C, Zaffina S, Locatelli F, Carsetti R, Quinti I. Piano Mortari E, et al. Front Immunol. 2023 May 25;14:1194225. doi: 10.3389/fimmu.2023.1194225. eCollection 2023. Front Immunol. 2023. PMID: 37304298 Free PMC article. - Role of B cells as antigen presenting cells.
Rastogi I, Jeon D, Moseman JE, Muralidhar A, Potluri HK, McNeel DG. Rastogi I, et al. Front Immunol. 2022 Sep 8;13:954936. doi: 10.3389/fimmu.2022.954936. eCollection 2022. Front Immunol. 2022. PMID: 36159874 Free PMC article. Review. - Berberine Delays Onset of Collagen-Induced Arthritis through T Cell Suppression.
Vita AA, Aljobaily H, Lyons DO, Pullen NA. Vita AA, et al. Int J Mol Sci. 2021 Mar 29;22(7):3522. doi: 10.3390/ijms22073522. Int J Mol Sci. 2021. PMID: 33805383 Free PMC article. - TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.
Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M. Staniek J, et al. Front Immunol. 2019 Apr 30;10:951. doi: 10.3389/fimmu.2019.00951. eCollection 2019. Front Immunol. 2019. PMID: 31114586 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials