Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia - PubMed (original) (raw)

Comparative Study

. 1995 Jun 6;211(1):74-82.

doi: 10.1006/bbrc.1995.1780.

Affiliations

• PMID: 7540007
• DOI: 10.1006/bbrc.1995.1780

Comparative Study

Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia

N A Essani et al. Biochem Biophys Res Commun. 1995.

Abstract

Intercellular adhesion molecule-1 (ICAM-1) and selectins (E- and P-selectin) mRNAs were determined in individual liver cell types by Northern blot analysis before and after injection of endotoxin. A constitutive expression of ICAM-1 mRNA was found in endothelial cells and Kupffer cells but not in hepatocytes. All three cell types showed upregulation of ICAM-1 mRNA after endotoxin. No constitutive selectin expression could be detected in any liver cell, but endotoxin induced massive synthesis of E- and P-selectin mRNA in endothelial cells and Kupffer cells. The differential expression of cellular adhesion molecules in the liver is consistent with the involvement of selectins in neutrophil rolling in the vasculature and ICAM-1 in transendothelial migration and adherence to parenchymal cells.

PubMed Disclaimer

Similar articles

• Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft.
  Zhu H, Guo YZ, Zhang J, Hu MD, Tang JH, Tian DG, A YJ, Sun F, Wei XP. Zhu H, et al. Hepatobiliary Pancreat Dis Int. 2007 Aug;6(4):379-82. Hepatobiliary Pancreat Dis Int. 2007. PMID: 17690033
• Expression of adhesion molecules during cadmium hepatotoxicity.
  Mousa SA. Mousa SA. Life Sci. 2004 May 21;75(1):93-105. doi: 10.1016/j.lfs.2003.12.010. Life Sci. 2004. PMID: 15102524
• Isolated Kupffer cells, endothelial cells and hepatocytes as investigative tools for liver research.
  Zahlten RN, Rogoff TM, Steer CJ. Zahlten RN, et al. Fed Proc. 1981 Aug;40(10):2460-8. Fed Proc. 1981. PMID: 7021184 Review.
• The role of eicosanoids and selectins in experimental asthma in monkeys.
  Gundel RH, Letts LG. Gundel RH, et al. Adv Prostaglandin Thromboxane Leukot Res. 1994;22:141-53. Adv Prostaglandin Thromboxane Leukot Res. 1994. PMID: 7539576 Review. No abstract available.

Cited by

• The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice.
  Bae CR, Zhang H, Kwon YG. Bae CR, et al. PLoS One. 2020 Dec 4;15(12):e0243497. doi: 10.1371/journal.pone.0243497. eCollection 2020. PLoS One. 2020. PMID: 33275637 Free PMC article.
• Maturation of the Acute Hepatic TLR4/NF-κB Mediated Innate Immune Response Is p65 Dependent in Mice.
  Zarate MA, Nguyen LM, De Dios RK, Zheng L, Wright CJ. Zarate MA, et al. Front Immunol. 2020 Aug 21;11:1892. doi: 10.3389/fimmu.2020.01892. eCollection 2020. Front Immunol. 2020. PMID: 32973783 Free PMC article.
• Role of liver ICAM-1 in metastasis.
  Benedicto A, Romayor I, Arteta B. Benedicto A, et al. Oncol Lett. 2017 Oct;14(4):3883-3892. doi: 10.3892/ol.2017.6700. Epub 2017 Aug 2. Oncol Lett. 2017. PMID: 28943897 Free PMC article.
• Sinusoidal communication in liver fibrosis and regeneration.
  Marrone G, Shah VH, Gracia-Sancho J. Marrone G, et al. J Hepatol. 2016 Sep;65(3):608-17. doi: 10.1016/j.jhep.2016.04.018. Epub 2016 May 2. J Hepatol. 2016. PMID: 27151183 Free PMC article. Review.
• Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.
  Woolbright BL, Li F, Xie Y, Farhood A, Fickert P, Trauner M, Jaeschke H. Woolbright BL, et al. Toxicol Lett. 2014 Jul 3;228(1):56-66. doi: 10.1016/j.toxlet.2014.04.001. Epub 2014 Apr 15. Toxicol Lett. 2014. PMID: 24742700 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Miscellaneous

  • NCI CPTAC Assay Portal