Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions - PubMed (original) (raw)

. 1995 Aug 31;376(6543):737-45.

doi: 10.1038/376737a0.

Affiliations

• PMID: 7544443
• DOI: 10.1038/376737a0

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

S Lev et al. Nature. 1995.

Abstract

The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.

PubMed Disclaimer

Comment in

• Signal transduction. Team blue sees red.
  Bourne HR. Bourne HR. Nature. 1995 Aug 31;376(6543):727-9. doi: 10.1038/376727a0. Nature. 1995. PMID: 7651531 No abstract available.

Similar articles

• Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.
  Zhong H, Minneman KP. Zhong H, et al. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):889-94. Biochem J. 1999. PMID: 10585878 Free PMC article.
• A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.
  Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. Dikic I, et al. Nature. 1996 Oct 10;383(6600):547-50. doi: 10.1038/383547a0. Nature. 1996. PMID: 8849729
• Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.
  Felsch JS, Cachero TG, Peralta EG. Felsch JS, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5051-6. doi: 10.1073/pnas.95.9.5051. Proc Natl Acad Sci U S A. 1998. PMID: 9560226 Free PMC article.
• Modulation of ion channels by protein phosphorylation and dephosphorylation.
  Levitan IB. Levitan IB. Annu Rev Physiol. 1994;56:193-212. doi: 10.1146/annurev.ph.56.030194.001205. Annu Rev Physiol. 1994. PMID: 7516643 Review.
• Modulation of ion channels by protein phosphorylation. How the brain works.
  Levitan IB. Levitan IB. Adv Second Messenger Phosphoprotein Res. 1999;33:3-22. doi: 10.1016/s1040-7952(99)80003-2. Adv Second Messenger Phosphoprotein Res. 1999. PMID: 10218112 Review. No abstract available.

Cited by

• Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.
  Zhong H, Minneman KP. Zhong H, et al. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):889-94. Biochem J. 1999. PMID: 10585878 Free PMC article.
• Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca(2+) and calmodulin.
  Egea J, Espinet C, Soler RM, Peiró S, Rocamora N, Comella JX. Egea J, et al. Mol Cell Biol. 2000 Mar;20(6):1931-46. doi: 10.1128/MCB.20.6.1931-1946.2000. Mol Cell Biol. 2000. PMID: 10688641 Free PMC article.
• Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling.
  Mousawi F, Peng H, Li J, Ponnambalam S, Roger S, Zhao H, Yang X, Jiang LH. Mousawi F, et al. Stem Cells. 2020 Mar;38(3):410-421. doi: 10.1002/stem.3114. Epub 2020 Jan 21. Stem Cells. 2020. PMID: 31746084 Free PMC article.
• Autophosphorylation of Tyr397 and its phosphorylation by Src-family kinases are altered in focal-adhesion-kinase neuronal isoforms.
  Toutant M, Studler JM, Burgaya F, Costa A, Ezan P, Gelman M, Girault JA. Toutant M, et al. Biochem J. 2000 May 15;348 Pt 1(Pt 1):119-28. Biochem J. 2000. PMID: 10794722 Free PMC article.
• Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.
  Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J. Gil-Henn H, et al. J Cell Biol. 2007 Sep 10;178(6):1053-64. doi: 10.1083/jcb.200701148. J Cell Biol. 2007. PMID: 17846174 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal