Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors - PubMed (original) (raw)
Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors
P Patel et al. BMJ. 1995.
Erratum in
- BMJ 1995 Oct 14;311(7011):985
Abstract
Objective: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors.
Design: Cross sectional study of a population based random sample of men. Coronary heart disease was assessed by electrocardiography, Rose angina questionnaire, and a history of myocardial infarction; serum antibody levels to H pylori and C pneumoniae were measured, risk factor levels determined, and a questionnaire administered.
Setting: General practices in Merton, Sutton, and Wandsworth, south London.
Subjects: 388 white south London men aged 50-69.
Main outcome measures: Evidence of coronary risk factors and infection with H pylori or C pneumoniae.
Results: 47 men (12.1%) had electrocardiographic evidence of ischaemia or infarction. 36 (76.6%) and 18 (38.3%) were seropositive for H pylori and C pneumoniae, respectively, compared with 155 (45.5%) and 62 (18.2%) men with normal electrocardiograms. Odds ratios for abnormal electrocardiograms were 3.82 (95% confidence interval 1.60 to 9.10) and 3.06 (1.33 to 7.01) in men seropositive for H pylori and C pneumoniae, respectively, after adjustment for a range of socioeconomic indicators and risk factors for coronary heart disease. Cardiovascular risk factors that were independently associated with seropositivity to H pylori included fibrinogen concentration and total leucocyte count. Seropositivity to C pneumoniae was independently associated with raised fibrinogen and malondialdehyde concentrations.
Conclusions: Both H pylori and C pneumoniae infectins are associated with coronary heart disease. These relations are not explained by a wide range of confounding factors. Possible mechanisms include an increase in risk factor levels due to a low grade chronic inflammatory response.
Comment in
- Association of Helicobacter pylori infection with coronary heart disease. Study shows association between H pylori infection and hypertension.
Lip GYH, Wise R, Beevers G. Lip GYH, et al. BMJ. 1996 Jan 27;312(7025):250-1. doi: 10.1136/bmj.312.7025.250b. BMJ. 1996. PMID: 8563608 Free PMC article. No abstract available. - Association of Helicobacter pylori infection with coronary heart disease. Association may not be causal.
Sandifer QD, Vuilo S, Crompton G. Sandifer QD, et al. BMJ. 1996 Jan 27;312(7025):251. doi: 10.1136/bmj.312.7025.251a. BMJ. 1996. PMID: 8563609 Free PMC article. No abstract available. - Association of Helicobacter pylori infection with coronary heart disease. Study confirms previous findings.
Ponzetto A, La Rovere MT, Sanseverino P, Bazzoli F. Ponzetto A, et al. BMJ. 1996 Jan 27;312(7025):251. doi: 10.1136/bmj.312.7025.251. BMJ. 1996. PMID: 8563610 Free PMC article. No abstract available. - Association of Helicobacter pylori infection with coronary heart disease. Eradication of the infection on grounds of cardiovascular risk is not supported by current evidence.
Delaney BC, Hobbs FD, Holder R. Delaney BC, et al. BMJ. 1996 Jan 27;312(7025):251-2. doi: 10.1136/bmj.312.7025.251b. BMJ. 1996. PMID: 8563611 Free PMC article. No abstract available.
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