p75 and Trk: a two-receptor system - PubMed (original) (raw)
Affiliations
- PMID: 7571013
Review
p75 and Trk: a two-receptor system
M V Chao et al. Trends Neurosci. 1995 Jul.
Abstract
The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of cell-surface proteins, the Trk family of receptor tyrosine kinases, and the p75, or low-affinity neurotrophin receptor. An important question is whether a dual receptor system is necessary for neurotrophin action. Evidence indicates that co-expression of the two genes for the p75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF, and suggests additional levels of regulation for the family of neurotrophin factors.
Similar articles
- Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors.
Donovan MJ, Hempstead B, Huber LJ, Kaplan D, Tsoulfas P, Chao M, Parada L, Schofield D. Donovan MJ, et al. Am J Pathol. 1994 Oct;145(4):792-801. Am J Pathol. 1994. PMID: 7943171 Free PMC article. - The p75 neurotrophin receptor.
Chao MV. Chao MV. J Neurobiol. 1994 Nov;25(11):1373-85. doi: 10.1002/neu.480251106. J Neurobiol. 1994. PMID: 7852992 Review. - The trk family of oncogenes and neurotrophin receptors.
Lamballe F, Klein R, Barbacid M. Lamballe F, et al. Princess Takamatsu Symp. 1991;22:153-70. Princess Takamatsu Symp. 1991. PMID: 1844238 Review. - Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.
Fundin BT, Silos-Santiago I, Ernfors P, Fagan AM, Aldskogius H, DeChiara TM, Phillips HS, Barbacid M, Yancopoulos GD, Rice FL. Fundin BT, et al. Dev Biol. 1997 Oct 1;190(1):94-116. doi: 10.1006/dbio.1997.8658. Dev Biol. 1997. PMID: 9331334 - Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.
Bibel M, Hoppe E, Barde YA. Bibel M, et al. EMBO J. 1999 Feb 1;18(3):616-22. doi: 10.1093/emboj/18.3.616. EMBO J. 1999. PMID: 9927421 Free PMC article.
Cited by
- Role of BDNF in central motor structures and motor diseases.
He YY, Zhang XY, Yung WH, Zhu JN, Wang JJ. He YY, et al. Mol Neurobiol. 2013 Dec;48(3):783-93. doi: 10.1007/s12035-013-8466-y. Epub 2013 May 7. Mol Neurobiol. 2013. PMID: 23649659 Review. - Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving.
Theberge FR, Pickens CL, Goldart E, Fanous S, Hope BT, Liu QR, Shaham Y. Theberge FR, et al. Psychopharmacology (Berl). 2012 Dec;224(4):559-71. doi: 10.1007/s00213-012-2784-z. Epub 2012 Jul 12. Psychopharmacology (Berl). 2012. PMID: 22790874 Free PMC article. - Divergent roles of p75NTR and Trk receptors in BDNF's effects on dendritic spine density and morphology.
Chapleau CA, Pozzo-Miller L. Chapleau CA, et al. Neural Plast. 2012;2012:578057. doi: 10.1155/2012/578057. Epub 2012 Mar 27. Neural Plast. 2012. PMID: 22548193 Free PMC article. - Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Willard MD, Willard FS, Li X, Cappell SD, Snider WD, Siderovski DP. Willard MD, et al. EMBO J. 2007 Apr 18;26(8):2029-40. doi: 10.1038/sj.emboj.7601659. Epub 2007 Mar 22. EMBO J. 2007. PMID: 17380122 Free PMC article. - A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor.
Murray SS, Perez P, Lee R, Hempstead BL, Chao MV. Murray SS, et al. J Neurosci. 2004 Mar 17;24(11):2742-9. doi: 10.1523/JNEUROSCI.3960-03.2004. J Neurosci. 2004. PMID: 15028767 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials