A novel serum protein similar to C1q, produced exclusively in adipocytes - PubMed (original) (raw)

. 1995 Nov 10;270(45):26746-9.

doi: 10.1074/jbc.270.45.26746.

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A novel serum protein similar to C1q, produced exclusively in adipocytes

P E Scherer et al. J Biol Chem. 1995.

Free article

Abstract

We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.

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