Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis - PubMed (original) (raw)
Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis
A Ghosh et al. Neuron. 1995 Jul.
Free article
Abstract
To identify molecules that regulate the transition of dividing neuroblasts to terminally differentiated neurons in the CNS, conditions have been developed that allow the neuronal differentiation of cortical precursor cells to be examined in vitro. In these cultures, the proliferation of undifferentiated precursor cells is controlled by basic fibroblast growth factor (bFGF). The proliferative effects of bFGF do not preclude the action of signals that promote differentiation, since addition of neurotrophin-3 (NT-3) antagonizes the proliferative effects of bFGF and enhances neuronal differentiation. In addition, blocking NT-3 function with neutralizing antibodies leads to a marked decrease in the number of differentiated neurons, without affecting the proliferation of cortical precursors or the survival of postmitotic cortical neurons. These observations suggest that bFGF and NT-3, by their distinct effects on cell proliferation and differentiation, are key regulators of neurogenesis in the CNS.
Comment in
- bFGF, neurotrophins, and the control or cortical neurogenesis.
Temple S, Qian X. Temple S, et al. Neuron. 1995 Aug;15(2):249-52. doi: 10.1016/0896-6273(95)90030-6. Neuron. 1995. PMID: 7646883 Review. No abstract available.
Similar articles
- Neurotrophins and basic fibroblast growth factor induce the differentiation of calbindin-containing neurons in the cerebral cortex.
Pappas IS, Parnavelas JG. Pappas IS, et al. Exp Neurol. 1997 Apr;144(2):302-14. doi: 10.1006/exnr.1997.6411. Exp Neurol. 1997. PMID: 9168831 - bFGF, neurotrophins, and the control or cortical neurogenesis.
Temple S, Qian X. Temple S, et al. Neuron. 1995 Aug;15(2):249-52. doi: 10.1016/0896-6273(95)90030-6. Neuron. 1995. PMID: 7646883 Review. No abstract available. - Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells.
Lukaszewicz A, Savatier P, Cortay V, Kennedy H, Dehay C. Lukaszewicz A, et al. J Neurosci. 2002 Aug 1;22(15):6610-22. doi: 10.1523/JNEUROSCI.22-15-06610.2002. J Neurosci. 2002. PMID: 12151540 Free PMC article. - Differential trophic effects of basic fibroblast growth factor, insulin-like growth factor-1, and neurotrophin-3 on striatal neurons in culture.
Nakao N, Odin P, Lindvall O, Brundin P. Nakao N, et al. Exp Neurol. 1996 Mar;138(1):144-57. doi: 10.1006/exnr.1996.0053. Exp Neurol. 1996. PMID: 8593889 - [Effect of environmental factor influencing the development of mouse cerebral cortex].
Fukumitsu H. Fukumitsu H. Yakugaku Zasshi. 2011;131(9):1317-21. doi: 10.1248/yakushi.131.1317. Yakugaku Zasshi. 2011. PMID: 21881305 Review. Japanese.
Cited by
- Gasdermin D Mediated Mitochondrial Metabolism Orchestrate Neurogenesis Through LDHA During Embryonic Development.
Ma H, Jia H, Zou W, Ji F, Wang W, Zhao J, Yuan C, Jiao J. Ma H, et al. Adv Sci (Weinh). 2024 Sep;11(35):e2402285. doi: 10.1002/advs.202402285. Epub 2024 Jul 21. Adv Sci (Weinh). 2024. PMID: 39033542 Free PMC article. - Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process.
Kasakura N, Murata Y, Shindo A, Kitaoka S, Furuyashiki T, Suzuki K, Segi-Nishida E. Kasakura N, et al. Front Neurosci. 2023 Jul 27;17:1178555. doi: 10.3389/fnins.2023.1178555. eCollection 2023. Front Neurosci. 2023. PMID: 37575306 Free PMC article. - BDNF and NGF Expression in Preneoplastic Cervical Disease According to HIV Status.
Sirico A, Simonelli S, Pignatiello S, Fulgione C, Sarno L, Chiuso F, Maruotti GM, Sansone M, Guida M, Insabato L. Sirico A, et al. Int J Mol Sci. 2023 Jun 27;24(13):10729. doi: 10.3390/ijms241310729. Int J Mol Sci. 2023. PMID: 37445902 Free PMC article. - Neuroligins facilitate the development of bone cancer pain via regulating synaptic transmission: an experimental study.
Xie X, Li Y, Su S, Li X, Xu X, Gao Y, Peng M, Ke C. Xie X, et al. Braz J Anesthesiol. 2024 Jul-Aug;74(4):744422. doi: 10.1016/j.bjane.2023.02.001. Epub 2023 Feb 24. Braz J Anesthesiol. 2024. PMID: 36841430 Free PMC article. - Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Shibata S, Shinozaki M, Shindo T, Hashimoto S, Kawai M, Kitagawa T, Ago K, Matsumoto M, Nakamura M, Okano H, Nagoshi N. Shibata T, et al. Stem Cells Transl Med. 2023 Mar 3;12(2):83-96. doi: 10.1093/stcltm/szac089. Stem Cells Transl Med. 2023. PMID: 36647673 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials