Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes - PubMed (original) (raw)

Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes

C L Miller et al. J Virol. 1993 Jun.

Abstract

LMP2A is expressed in latent Epstein-Barr virus (EBV) infection and interacts with LMP1 and members of the src tyrosine kinase family in the plasma membrane. Since tyrosine kinase mediate receptor-induced changes in intracellular free calcium, the effect of LMP2A on receptor-mediated intracellular calcium mobilization was evaluated by stably expressing LMP2A in an EBV-negative Burkitt tumor cell line (BJAB) or in LMP1-converted BJAB cells. LMP2A significantly blocked calcium mobilization following class II, CD19, or immunoglobulin M cross-linking. LMP2A effects were partially reversed in LMP1-converted cell lines. These results are compatible with LMP2A acting in latent B-lymphocyte infection to downmodulate LMP1 effects on cell growth or to inhibit induction of lytic EBV infection in specific human tissues following receptor ligation.

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References

    1. J Immunol. 1987 Jan 1;138(1):98-103 - PubMed
    1. Biochem Biophys Res Commun. 1986 Nov 14;140(3):1079-85 - PubMed
    1. Immunol Rev. 1987 Feb;95:37-57 - PubMed
    1. Mol Cell Biol. 1987 Nov;7(11):3923-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1897-901 - PubMed

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