Protein kinase C zeta isoform is critical for mitogenic signal transduction - PubMed (original) (raw)
Protein kinase C zeta isoform is critical for mitogenic signal transduction
E Berra et al. Cell. 1993.
Abstract
The requirement of protein kinase C zeta (zeta PKC) for maturation of X. laevis oocytes in response to insulin, p21ras, and phosphatidylcholine-hydrolyzing phospholipase C has recently been shown. Here we present experimental evidence demonstrating that activation of zeta PKC is not only necessary but also sufficient by itself to activate maturation in oocytes and to produce deregulation of growth control in mouse fibroblasts. Furthermore, by using a dominant kinase-defective mutant of zeta PKC, we confirm that this kinase is required for mitogenic activation in oocytes and fibroblasts. These results permit us to propose zeta PKC as a critical step downstream of p21ras in mitogenic signal transduction.
Similar articles
- Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta.
van Dijk M, Muriana FJ, van Der Hoeven PC, de Widt J, Schaap D, Moolenaar WH, van Blitterswijk WJ. van Dijk M, et al. Biochem J. 1997 May 1;323 ( Pt 3)(Pt 3):693-9. doi: 10.1042/bj3230693. Biochem J. 1997. PMID: 9169602 Free PMC article. - Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes.
Carnero A, Liyanage M, Stabel S, Lacal JC. Carnero A, et al. Oncogene. 1995 Oct 19;11(8):1541-7. Oncogene. 1995. PMID: 7478578 - Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.
Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J. Dominguez I, et al. Mol Cell Biol. 1992 Sep;12(9):3776-83. doi: 10.1128/mcb.12.9.3776-3783.1992. Mol Cell Biol. 1992. PMID: 1508183 Free PMC article. - Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
Diaz-Meco MT, Lozano J, Municio MM, Berra E, Frutos S, Sanz L, Moscat J. Diaz-Meco MT, et al. J Biol Chem. 1994 Dec 16;269(50):31706-10. J Biol Chem. 1994. PMID: 7989344 - Role of p21ras in growth factor signal transduction.
Burgering BM, Pronk GJ, Medema JP, van der Voorn L, de Vries Smits AM, van Weeren PC, Bos JL. Burgering BM, et al. Biochem Soc Trans. 1993 Nov;21(4):888-94. doi: 10.1042/bst0210888. Biochem Soc Trans. 1993. PMID: 8132088 Review. No abstract available.
Cited by
- Nonesterified fatty acids in blood pressure control and cardiovascular complications.
Egan BM, Greene EL, Goodfriend TL. Egan BM, et al. Curr Hypertens Rep. 2001 Apr;3(2):107-16. doi: 10.1007/s11906-001-0021-y. Curr Hypertens Rep. 2001. PMID: 11276390 Review. - Programmed cell death in neurotumour cells involves the generation of ceramide.
Wiesner DA, Dawson G. Wiesner DA, et al. Glycoconj J. 1996 Apr;13(2):327-33. doi: 10.1007/BF00731508. Glycoconj J. 1996. PMID: 8737258 - An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3.
Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T, Tabuse Y, Kemphues KJ, Ohno S. Izumi Y, et al. J Cell Biol. 1998 Oct 5;143(1):95-106. doi: 10.1083/jcb.143.1.95. J Cell Biol. 1998. PMID: 9763423 Free PMC article. - Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin.
Mendez R, Kollmorgen G, White MF, Rhoads RE. Mendez R, et al. Mol Cell Biol. 1997 Sep;17(9):5184-92. doi: 10.1128/MCB.17.9.5184. Mol Cell Biol. 1997. PMID: 9271396 Free PMC article. - EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.
Akimoto K, Takahashi R, Moriya S, Nishioka N, Takayanagi J, Kimura K, Fukui Y, Osada Si, Mizuno K, Hirai Si, Kazlauskas A, Ohno S. Akimoto K, et al. EMBO J. 1996 Feb 15;15(4):788-98. EMBO J. 1996. PMID: 8631300 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials