Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission - PubMed (original) (raw)

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

H Fujii et al. Proc Natl Acad Sci U S A. 1995.

Abstract

The high-affinity interleukin 2 (IL-2) receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta c, and IL-2R gamma c chains. Two members of the Janus kinase family, Jak1 and Jak3, are associated with IL-2R beta c and IL-2R gamma c, respectively, and they are activated upon IL-2 stimulation. The cytokine-mediated Jak kinase activation usually results in the activation of a family of latent transcription factors termed Stat (signal transducer and activator of transcription) proteins. Recently, the IL-2-induced Stat protein was purified from human lymphocytes and found to be the homologue of sheep Stat5/mammary gland factor. We demonstrate that the human Stat5 is activated by IL-2 and that Jak3 is required for the efficient activation. The cytoplasmic region of the IL-2R beta c chain required for activation of Stat5 is mapped within the carboxyl-terminal 147 amino acids. On the other hand, this region is not essential for IL-2-induced cell proliferation.

PubMed Disclaimer

Similar articles

• Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line.
  Higuchi M, Asao H, Tanaka N, Oda K, Takeshita T, Nakamura M, Van Snick J, Sugamura K. Higuchi M, et al. Eur J Immunol. 1996 Jun;26(6):1322-7. doi: 10.1002/eji.1830260622. Eur J Immunol. 1996. PMID: 8647212
• Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
  Kirken RA, Rui H, Malabarba MG, Howard OM, Kawamura M, O'Shea JJ, Farrar WL. Kirken RA, et al. Cytokine. 1995 Oct;7(7):689-700. doi: 10.1006/cyto.1995.0081. Cytokine. 1995. PMID: 8580378
• Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
  Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM, Wasik MA. Zhang Q, et al. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9148-53. doi: 10.1073/pnas.93.17.9148. Proc Natl Acad Sci U S A. 1996. PMID: 8799169 Free PMC article.
• The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.
  Lin JX, Leonard WJ. Lin JX, et al. Oncogene. 2000 May 15;19(21):2566-76. doi: 10.1038/sj.onc.1203523. Oncogene. 2000. PMID: 10851055 Review.
• IL-2 signaling involves recruitment and activation of multiple protein tyrosine kinases by the IL-2 receptor.
  Taniguchi T, Miyazaki T, Minami Y, Kawahara A, Fujii H, Nakagawa Y, Hatakeyama M, Liu ZJ. Taniguchi T, et al. Ann N Y Acad Sci. 1995 Sep 7;766:235-44. doi: 10.1111/j.1749-6632.1995.tb26671.x. Ann N Y Acad Sci. 1995. PMID: 7486666 Review.

Cited by

• Recent advances in the understanding of interleukin-2 signal transduction.
  Gesbert F, Delespine-Carmagnat M, Bertoglio J. Gesbert F, et al. J Clin Immunol. 1998 Sep;18(5):307-20. doi: 10.1023/a:1023223614407. J Clin Immunol. 1998. PMID: 9793823 Review.
• Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.
  Fujii H. Fujii H. Biochem Biophys Res Commun. 2007 Mar 16;354(3):825-9. doi: 10.1016/j.bbrc.2007.01.067. Epub 2007 Jan 22. Biochem Biophys Res Commun. 2007. PMID: 17266928 Free PMC article.
• Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription.
  Stoecklin E, Wissler M, Moriggl R, Groner B. Stoecklin E, et al. Mol Cell Biol. 1997 Nov;17(11):6708-16. doi: 10.1128/MCB.17.11.6708. Mol Cell Biol. 1997. PMID: 9343435 Free PMC article.
• Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation.
  Chrétien S, Varlet P, Verdier F, Gobert S, Cartron JP, Gisselbrecht S, Mayeux P, Lacombe C. Chrétien S, et al. EMBO J. 1996 Aug 15;15(16):4174-81. EMBO J. 1996. PMID: 8861946 Free PMC article.

References

1. 1. Science. 1989 May 5;244(4904):551-6 - PubMed
2. 1. Immunol Rev. 1994 Apr;138:61-86 - PubMed
3. 1. Annu Rev Biochem. 1989;58:875-911 - PubMed
4. 1. Cell. 1989 Dec 1;59(5):837-45 - PubMed
5. 1. Cell. 1990 Oct 19;63(2):303-12 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal