Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p - PubMed (original) (raw)
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Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p
J Hazan et al. Hum Mol Genet. 1994 Sep.
Abstract
Autosomal dominant familial spastic paraplegia (AD-FSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21-p24 in five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.
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